Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement

T. Yee Khong*, Eoghan E. Mooney, Ilana Ariel, Nathalie C. M. Balmus, Theonia K. Boyd, Marie-Anne Brundler, Hayley Derricott, Margaret J. Evans, Ona M. Faye-Petersen, John E. Gillan, Alex E. P. Heazell, Debra S. Heller, Suzanne M. Jacques, Sarah Keating, Peter Kelehan, Ann Maes, Eileen M. McKay, Terry K. Morgan, Peter G. J. Nikkels, W. Tony ParksRaymond W. Redline, Irene Scheimberg, Mirthe H. Schoots, Neil J. Sebire, Albert Timmer, Gitta Turowski, J. Patrick van der Voorn, Ineke van Lijnschoten, Sanne J. Gordijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

384 Citations (Scopus)

Abstract

Context.-The value of placental examination in investigations of adverse pregnancy outcomes may be compromised by sampling and definition differences between laboratories.

Objective.-To establish an agreed-upon protocol for sampling the placenta, and for diagnostic criteria for placental lesions. Recommendations would cover reporting placentas in tertiary centers as well as in community hospitals and district general hospitals, and are also relevant to the scientific research community.

Data Sources.-Areas of controversy or uncertainty were explored prior to a 1-day meeting where placental and perinatal pathologists, and maternal-fetal medicine specialists discussed available evidence and subsequently reached consensus where possible.

Conclusions.-The group agreed on sets of uniform sampling criteria, placental gross descriptors, pathologic terminologies, and diagnostic criteria. The terminology and microscopic descriptions for maternal vascular malperfusion, fetal vascular malperfusion, delayed villous maturation, patterns of ascending intrauterine infection, and villitis of unknown etiology were agreed upon. Topics requiring further discussion were highlighted. Ongoing developments in our understanding of the pathology of the placenta, scientific bases of the maternofetoplacental triad, and evolution of the clinical significance of defined lesions may necessitate further refinements of these consensus guidelines. The proposed structure will assist in international comparability of clinicopathologic and scientific studies and assist in refining the significance of lesions associated with adverse pregnancy and later health outcomes.

Original languageEnglish
Pages (from-to)698-713
Number of pages16
JournalArchives of pathology & laboratory medicine
Volume140
Issue number7
DOIs
Publication statusPublished - Jul-2016

Keywords

  • FETAL THROMBOTIC VASCULOPATHY
  • UMBILICAL-CORD COILING
  • CELL CHORIONIC VASCULITIS
  • GESTATIONAL-AGE INFANTS
  • REACTION PATTERNS
  • BIRTH-WEIGHT
  • CLINICAL-SIGNIFICANCE
  • GROWTH RESTRICTION
  • OXIDATIVE STRESS
  • PRETERM BIRTH

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