Sarcoidosis presenting with glazy mucoid sputum and dyspnea: a case report

Wud Al-Kailany, Wim Timens, Ben Venmans, Gonda de Jonge, Tjip S van der Werf*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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BACKGROUND: Patients with pulmonary sarcoidosis commonly present with a dry cough; a productive cough suggests a complicating airway infection or an alternative diagnosis such as tuberculosis or bronchiectasis.

CASE PRESENTATION: A 36-year-old European (Frisian) woman recently diagnosed with pulmonary sarcoidosis presented with debilitating exertional dyspnea and cough productive of glazy mucoid sputum. Several different attempts including video-assisted thoracoscopic biopsies failed to reach a second or alternative diagnosis including an infectious, autoimmune or collagen-vascular condition. She responded to steroids but with poor tolerance to this treatment, which could not be tapered. After she was started on anti-tumor necrosis factor alpha (TNF-α) therapy with infliximab, 200 mg at three-monthly intervals, she has been fine for well over a decade.

CONCLUSIONS: In this patient with sarcoidosis who had a productive cough accompanied by fever, an extensive workup and prolonged follow-up, an alternative or second diagnosis could be ruled out; we therefore conclude that this highly unusual presentation is part of the clinical spectrum of sarcoidosis.

Original languageEnglish
Article number232
Number of pages5
JournalJournal of Medical Case Reports
Issue number1
Publication statusE-pub ahead of print - 11-May-2021


  • Adult
  • Dyspnea/etiology
  • Female
  • Humans
  • Infliximab
  • Sarcoidosis/complications
  • Sarcoidosis, Pulmonary/complications
  • Sputum

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