Saved by the Matrix: UPR Independent Survival under ER Stress

Mandy Koopman; Claudio Hetz; Ellen A A Nollen

doi:10.1016/j.cell.2019.11.012

Saved by the Matrix: UPR Independent Survival under ER Stress

Mandy Koopman, Claudio Hetz, Ellen A A Nollen^*

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic

8 Citations (Scopus)

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Abstract

Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

Original language	English
Pages (from-to)	1246-1248
Number of pages	3
Journal	Cell
Volume	179
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2019.11.012
Publication status	Published - 27-Nov-2019

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Saved by the Matrix_ UPR Independent Survival under ER Stress _ Elsevier Enhanced ReaderFinal publisher's version, 1.89 MBLicence: Taverne

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@article{c78e8ae02f0742919673179e2e0b6934,

title = "Saved by the Matrix: UPR Independent Survival under ER Stress",

abstract = "Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.",

author = "Mandy Koopman and Claudio Hetz and Nollen, {Ellen A A}",

year = "2019",

month = nov,

day = "27",

doi = "10.1016/j.cell.2019.11.012",

language = "English",

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journal = "Cell",

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TY - JOUR

T1 - Saved by the Matrix

T2 - UPR Independent Survival under ER Stress

AU - Koopman, Mandy

AU - Hetz, Claudio

AU - Nollen, Ellen A A

PY - 2019/11/27

Y1 - 2019/11/27

N2 - Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

AB - Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

U2 - 10.1016/j.cell.2019.11.012

DO - 10.1016/j.cell.2019.11.012

M3 - Editorial

C2 - 31778650

SN - 0092-8674

VL - 179

SP - 1246

EP - 1248

JO - Cell

JF - Cell

IS - 6

ER -

Saved by the Matrix: UPR Independent Survival under ER Stress

Abstract

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