TY - JOUR
T1 - Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
AU - Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
AU - Piñana, Jose Luis
AU - Xhaard, Aliénor
AU - Tridello, Gloria
AU - Passweg, Jakob
AU - Kozijn, Anne
AU - Polverelli, Nicola
AU - Heras, Inmaculada
AU - Perez, Ariadna
AU - Sanz, Jaime
AU - Berghuis, Dagmar
AU - Vázquez, Lourdes
AU - Suárez-Lledó, María
AU - Itäla-Remes, Maija
AU - Ozcelik, Tulay
AU - Iturrate Basarán, Isabel
AU - Karakukcu, Musa
AU - Al Zahrani, Mohsen
AU - Choi, Goda
AU - Cuesta Casas, Marián Angeles
AU - Batlle Massana, Montserrat
AU - Viviana, Amato
AU - Blijlevens, Nicole
AU - Ganser, Arnold
AU - Kuskonmaz, Baris
AU - Labussière-Wallet, Hélène
AU - Shaw, Peter J
AU - Arzu Yegin, Zeynep
AU - González-Vicent, Marta
AU - Rocha, Vanderson
AU - Ferster, Alina
AU - Knelange, Nina
AU - Navarro, David
AU - Mikulska, Malgorzata
AU - de la Camara, Rafael
AU - Styczynski, Jan
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte countConclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
AB - Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte countConclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
KW - seasonal human coronavirus
KW - HCoV-NL63
KW - HCoV-229E
KW - HCoV-OC43
KW - HCoV-HKU1
KW - community-acquired respiratory virus
KW - allogeneic hematopoietic stem cell transplantation
KW - immunocompromised
KW - upper and lower respiratory tract disease
KW - immunodeficiency score index
KW - multiplex PCR assay
KW - CLINICAL CHARACTERISTICS
KW - PARAINFLUENZA VIRUS
KW - NL63 INFECTIONS
KW - SYNCYTIAL VIRUS
KW - PNEUMONIA
KW - DISEASE
KW - RHINOVIRUS
KW - DIAGNOSIS
KW - OUTCOMES
KW - CHINA
U2 - 10.1093/infdis/jiaa553
DO - 10.1093/infdis/jiaa553
M3 - Article
C2 - 32860509
SN - 1537-6613
VL - 223
SP - 1564
EP - 1575
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 9
ER -