Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH); Jose Luis Piñana; Aliénor Xhaard; Gloria Tridello; Jakob Passweg; Anne Kozijn; Nicola Polverelli; Inmaculada Heras; Ariadna Perez; Jaime Sanz; Dagmar Berghuis; Lourdes Vázquez; María Suárez-Lledó; Maija Itäla-Remes; Tulay Ozcelik; Isabel Iturrate Basarán; Musa Karakukcu; Mohsen Al Zahrani; Goda Choi; Marián Angeles Cuesta Casas; Montserrat Batlle Massana; Amato Viviana; Nicole Blijlevens; Arnold Ganser; Baris Kuskonmaz; Hélène Labussière-Wallet; Peter J Shaw; Zeynep Arzu Yegin; Marta González-Vicent; Vanderson Rocha; Alina Ferster; Nina Knelange; David Navarro; Malgorzata Mikulska; Rafael de la Camara; Jan Styczynski

doi:10.1093/infdis/jiaa553

Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
, Jose Luis Piñana
, Aliénor Xhaard
, Gloria Tridello
, Jakob Passweg
, Anne Kozijn
, Nicola Polverelli
, Inmaculada Heras
, Ariadna Perez
, Jaime Sanz
, Dagmar Berghuis
, Lourdes Vázquez
, María Suárez-Lledó
, Maija Itäla-Remes
, Tulay Ozcelik
, Isabel Iturrate Basarán
, Musa Karakukcu
, Mohsen Al Zahrani
, Goda Choi
, Marián Angeles Cuesta Casas

Montserrat Batlle Massana, Amato Viviana, Nicole Blijlevens, Arnold Ganser, Baris Kuskonmaz, Hélène Labussière-Wallet, Peter J Shaw, Zeynep Arzu Yegin, Marta González-Vicent, Vanderson Rocha, Alina Ferster, Nina Knelange, David Navarro, Malgorzata Mikulska, Rafael de la Camara, Jan Styczynski

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

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Abstract

Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).

Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.

Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count

Conclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.

Original language	English
Pages (from-to)	1564-1575
Number of pages	12
Journal	The Journal of Infectious Diseases
Volume	223
Issue number	9
Early online date	29-Aug-2020
DOIs	https://doi.org/10.1093/infdis/jiaa553
Publication status	Published - 1-May-2021

Keywords

seasonal human coronavirus
HCoV-NL63
HCoV-229E
HCoV-OC43
HCoV-HKU1
community-acquired respiratory virus
allogeneic hematopoietic stem cell transplantation
immunocompromised
upper and lower respiratory tract disease
immunodeficiency score index
multiplex PCR assay
CLINICAL CHARACTERISTICS
PARAINFLUENZA VIRUS
NL63 INFECTIONS
SYNCYTIAL VIRUS
PNEUMONIA
DISEASE
RHINOVIRUS
DIAGNOSIS
OUTCOMES
CHINA

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Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, J. L., Xhaard, A., Tridello, G., Passweg, J., Kozijn, A., Polverelli, N., Heras, I., Perez, A., Sanz, J., Berghuis, D., Vázquez, L., Suárez-Lledó, M., Itäla-Remes, M., Ozcelik, T., Iturrate Basarán, I., Karakukcu, M., Al Zahrani, M., Choi, G., ... Styczynski, J. (2021). Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. The Journal of Infectious Diseases, 223(9), 1564-1575. https://doi.org/10.1093/infdis/jiaa553

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH) ; Piñana, Jose Luis ; Xhaard, Aliénor et al. / Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. In: The Journal of Infectious Diseases. 2021 ; Vol. 223, No. 9. pp. 1564-1575.

@article{da2b524ad07043cf9ec63f295fd9f7ac,

title = "Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation",

abstract = "Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38\%]). LRTD involvement occurred in 121 episodes (27\%). HCoV infection frequently required hospitalization (18\%), oxygen administration (13\%), and intensive care unit (ICU) admission (3\%). Three-month overall mortality after HCoV detection was 7\% in the whole cohort and 16\% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte countConclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.",

keywords = "seasonal human coronavirus, HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1, community-acquired respiratory virus, allogeneic hematopoietic stem cell transplantation, immunocompromised, upper and lower respiratory tract disease, immunodeficiency score index, multiplex PCR assay, CLINICAL CHARACTERISTICS, PARAINFLUENZA VIRUS, NL63 INFECTIONS, SYNCYTIAL VIRUS, PNEUMONIA, DISEASE, RHINOVIRUS, DIAGNOSIS, OUTCOMES, CHINA",

author = "\{Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)\} and Pi{\~n}ana, \{Jose Luis\} and Ali{\'e}nor Xhaard and Gloria Tridello and Jakob Passweg and Anne Kozijn and Nicola Polverelli and Inmaculada Heras and Ariadna Perez and Jaime Sanz and Dagmar Berghuis and Lourdes V{\'a}zquez and Mar{\'i}a Su{\'a}rez-Lled{\'o} and Maija It{\"a}la-Remes and Tulay Ozcelik and \{Iturrate Basar{\'a}n\}, Isabel and Musa Karakukcu and \{Al Zahrani\}, Mohsen and Goda Choi and \{Cuesta Casas\}, \{Mari{\'a}n Angeles\} and \{Batlle Massana\}, Montserrat and Amato Viviana and Nicole Blijlevens and Arnold Ganser and Baris Kuskonmaz and H{\'e}l{\`e}ne Labussi{\`e}re-Wallet and Shaw, \{Peter J\} and \{Arzu Yegin\}, Zeynep and Marta Gonz{\'a}lez-Vicent and Vanderson Rocha and Alina Ferster and Nina Knelange and David Navarro and Malgorzata Mikulska and \{de la Camara\}, Rafael and Jan Styczynski",

year = "2021",

month = may,

day = "1",

doi = "10.1093/infdis/jiaa553",

language = "English",

volume = "223",

pages = "1564--1575",

journal = "The Journal of Infectious Diseases",

issn = "1537-6613",

publisher = "Oxford University Press",

number = "9",

}

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, JL, Xhaard, A, Tridello, G, Passweg, J, Kozijn, A, Polverelli, N, Heras, I, Perez, A, Sanz, J, Berghuis, D, Vázquez, L, Suárez-Lledó, M, Itäla-Remes, M, Ozcelik, T, Iturrate Basarán, I, Karakukcu, M, Al Zahrani, M, Choi, G, Cuesta Casas, MA, Batlle Massana, M, Viviana, A, Blijlevens, N, Ganser, A, Kuskonmaz, B, Labussière-Wallet, H, Shaw, PJ, Arzu Yegin, Z, González-Vicent, M, Rocha, V, Ferster, A, Knelange, N, Navarro, D, Mikulska, M, de la Camara, R & Styczynski, J 2021, 'Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation', The Journal of Infectious Diseases, vol. 223, no. 9, pp. 1564-1575. https://doi.org/10.1093/infdis/jiaa553

Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. / Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH); Piñana, Jose Luis; Xhaard, Aliénor et al.
In: The Journal of Infectious Diseases, Vol. 223, No. 9, 01.05.2021, p. 1564-1575.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

AU - Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)

AU - Piñana, Jose Luis

AU - Xhaard, Aliénor

AU - Tridello, Gloria

AU - Passweg, Jakob

AU - Kozijn, Anne

AU - Polverelli, Nicola

AU - Heras, Inmaculada

AU - Perez, Ariadna

AU - Sanz, Jaime

AU - Berghuis, Dagmar

AU - Vázquez, Lourdes

AU - Suárez-Lledó, María

AU - Itäla-Remes, Maija

AU - Ozcelik, Tulay

AU - Iturrate Basarán, Isabel

AU - Karakukcu, Musa

AU - Al Zahrani, Mohsen

AU - Choi, Goda

AU - Cuesta Casas, Marián Angeles

AU - Batlle Massana, Montserrat

AU - Viviana, Amato

AU - Blijlevens, Nicole

AU - Ganser, Arnold

AU - Kuskonmaz, Baris

AU - Labussière-Wallet, Hélène

AU - Shaw, Peter J

AU - Arzu Yegin, Zeynep

AU - González-Vicent, Marta

AU - Rocha, Vanderson

AU - Ferster, Alina

AU - Knelange, Nina

AU - Navarro, David

AU - Mikulska, Malgorzata

AU - de la Camara, Rafael

AU - Styczynski, Jan

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte countConclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.

AB - Background. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which induded allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019.Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte countConclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.

KW - seasonal human coronavirus

KW - HCoV-NL63

KW - HCoV-229E

KW - HCoV-OC43

KW - HCoV-HKU1

KW - community-acquired respiratory virus

KW - allogeneic hematopoietic stem cell transplantation

KW - immunocompromised

KW - upper and lower respiratory tract disease

KW - immunodeficiency score index

KW - multiplex PCR assay

KW - CLINICAL CHARACTERISTICS

KW - PARAINFLUENZA VIRUS

KW - NL63 INFECTIONS

KW - SYNCYTIAL VIRUS

KW - PNEUMONIA

KW - DISEASE

KW - RHINOVIRUS

KW - DIAGNOSIS

KW - OUTCOMES

KW - CHINA

U2 - 10.1093/infdis/jiaa553

DO - 10.1093/infdis/jiaa553

M3 - Article

C2 - 32860509

SN - 1537-6613

VL - 223

SP - 1564

EP - 1575

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 9

ER -

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana JL, Xhaard A, Tridello G, Passweg J, Kozijn A et al. Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. The Journal of Infectious Diseases. 2021 May 1;223(9):1564-1575. Epub 2020 Aug 29. doi: 10.1093/infdis/jiaa553

Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

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