Seasonal Variations in the Deoxypodophyllotoxin Content and Yield of Anthriscus sylvestris L. (Hoffm.) Grown in the Field and under Controlled Conditions

Oktavia Hendrawati, Herman J. Woerdenbag, Jacques Hille, Wim J. Quax, Oliver Kayser*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
439 Downloads (Pure)

Abstract

Deoxypodophyllotoxin (DPT) is the main lignan in Anthriscus sylvestris. For this study two sets of experiments with 16 plants and seeds, collected from a wide geographical range, were carried out. The DPT content in roots was significantly lower (p <0.05) when the plants were cultivated in a non-native environment. For field-grown plants the highest DPT content was found in March (second year): 0.15% w/w (dry weight) in roots; 0.03% w/w in aerial parts. For plants grown in the climate room, the highest concentration (0.14% w/w) was observed in April (second year) in the roots and in July (first year) in the aerial parts (0.05% w/w). For the isolation of DPT, roots are the most suitable part. The best harvest times are March (second year) for outdoor plants and April (second year) for indoor plants when height content and adequate biomass give the optimal DPT yield.

Original languageEnglish
Pages (from-to)8132-8139
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number15
DOIs
Publication statusPublished - 10-Aug-2011

Keywords

  • lignan
  • deoxypodophyllotoxin
  • podophyllotoxin
  • Anthriscus sylvestris
  • environmental factors
  • plant cultivation
  • biosynthesis
  • etoposide
  • teniposide
  • CELL-SUSPENSION CULTURES
  • PODOPHYLLUM-HEXANDRUM
  • INSECTICIDAL ACTIVITY
  • LIGNANS
  • EXPRESSION
  • PLANTS
  • DERIVATIVES
  • ROOT

Cite this