Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach

Johannes A. Langendijk*, Philippe Lambin, Dirk De Ruysscher, Joachim Widder, Mike Bos, Marcel Verheij

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

251 Citations (Scopus)

Abstract

Most new radiation techniques, have been introduced primarily to reduce the dose to normal tissues in order to prevent radiation-induced side effects. Radiotherapy with protons is such a radiation technique that due to its superior beam properties compared to photons enables better sparing of normal tissues. This paper describes a stepwise methodology to select patients for proton therapy when the primary aim is to reduce side effects. This method has been accepted by the Dutch health authorities to select patients for proton therapy. In addition, an alternative method is described in case randomised controlled trials are considered not appropriate. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalRadiotherapy and Oncology
Volume107
Issue number3
DOIs
Publication statusPublished - Jun-2013

Keywords

  • Proton therapy
  • Patient selection
  • Randomisation
  • NTCP-models
  • QUALITY-OF-LIFE
  • 3-DIMENSIONAL CONFORMAL RADIOTHERAPY
  • INTENSITY-MODULATED RADIOTHERAPY
  • NECK-CANCER
  • LUNG-CANCER
  • NTCP MODELS
  • STICKY SALIVA
  • TREATMENT UNCERTAINTIES
  • EXTERNAL VALIDATION
  • RATED XEROSTOMIA

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