Selenium and heart failure

This thesis investigates the relationship between selenium levels and heart failure. Selenium, a crucial micronutrient essential for the normal functioning of several proteins and enzymes, has been previously linked to increased mortality and deteriorated quality of life in patients with heart failure. Our studies further examine how selenium relates to newly diagnosed heart failure and atrial fibrillation in the general population. We discovered that individuals with low selenium levels, particularly non-smokers, face a higher risk of developing these highly prevalent heart conditions, highlighting the nutrient’s crucial role in cardiovascular health. The research also reveals gender-specific impacts: women with low selenium levels are more prone to diabetes, have higher body mass index (BMI), and experience more heart attacks compared to men. It's important to note, however, that the observational nature of these studies does not prove causality. Additionally, the thesis explores selenium’s potential effects on the immune system and its role in reducing inflammation and oxidative stress in heart tissues, which might help slow the progression of heart failure. Collectively, these findings point to selenium's potential as a therapeutic agent, especially in those with low selenium concentrations. This thesis makes an important contribution by paving the way for the first registry-based clinical trial in the Netherlands to assess the effectiveness of selenium treatments in heart failure, aiming to improve long-term outcomes and quality of life for patients.