Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Ali A. Al-Mubarak; Peter van der Meer; Nils Bomer

doi:10.1007/s11897-021-00511-4

Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Ali A. Al-Mubarak, Peter van der Meer, Nils Bomer^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

55 Citations (Scopus)

137 Downloads (Pure)

Abstract

Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins.

Recent Findings Suboptimal selenium levels (

Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints.

Original language	English
Pages (from-to)	122-131
Number of pages	10
Journal	Current heart failure reports
Volume	18
Issue number	3
DOIs	https://doi.org/10.1007/s11897-021-00511-4
Publication status	Published - Jun-2021

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title = "Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective",

abstract = "Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins.Recent Findings Suboptimal selenium levels (Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints.",

author = "Al-Mubarak, {Ali A.} and {van der Meer}, Peter and Nils Bomer",

year = "2021",

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doi = "10.1007/s11897-021-00511-4",

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T1 - Selenium, Selenoproteins, and Heart Failure

T2 - Current Knowledge and Future Perspective

AU - Al-Mubarak, Ali A.

AU - van der Meer, Peter

AU - Bomer, Nils

PY - 2021/6

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N2 - Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins.Recent Findings Suboptimal selenium levels (Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints.

AB - Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins.Recent Findings Suboptimal selenium levels (Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints.

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JO - Current heart failure reports

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Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

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