Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Ali A. Al-Mubarak, Peter van der Meer, Nils Bomer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
50 Downloads (Pure)

Abstract

Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins.

Recent Findings Suboptimal selenium levels (

Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints.

Original languageEnglish
Pages (from-to)122-131
Number of pages10
JournalCurrent heart failure reports
Volume18
Issue number3
DOIs
Publication statusPublished - Jun-2021

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