Self-Rated Health Predicts Mortality and Graft Loss after Kidney Transplantation: A 10-Year Follow-Up Study

Maria Majernikova*, Jaroslav Rosenberger, Lucia Prihodova, Iveta Nagyova, Robert Roland, Johan W. Groothoff, Jitse P. van Dijk

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
327 Downloads (Pure)

Abstract

Background: This study explored whether self-rated health (SRH) shortly after kidney transplantation (KT) predicts mortality and graft loss at up to 10 years' follow-up. Methods: A total of 276 patients shortly after successful KT were interviewed. SRH was measured using the first item of the SF-36 questionnaire and divided into three tertiles: poor, average and excellent health. Clinical data were retrieved from medical records. Cox regression was used to identify whether different levels of SRH predicted mortality and graft loss in transplant recipients. The observation period was up to 10 years. Results: Poor SRH (HR 11.1, p <0.001), average SRH (HR 4.21, p <0.05), estimated glomerular filtration rate (HR 0.26, p <0.05) and age (HR 1.04, p <0.05) were significantly associated with mortality. Similarly, poor SRH (HR 6.4, p <0.001), average SRH (HR 3.6, p <0.05), new-onset diabetes mellitus after KT (HR 3.3, p <0.05) and chronic renal allograft dysfunction (HR 3.7, p <0.00) were significantly associated with graft loss. Conclusion: Poor SRH shortly after transplantation indicates an increased risk of mortality and graft loss at up to 10 years' follow-up. SRH could be an inexpensive and reliable indicator for starting diagnostic and/or treatment strategies. The usefulness of SRH compared to other global clinical measures predicting mortality and graft loss should also be studied. Copyright (C) 2012 S. Karger AG, Basel

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalAmerican Journal of Nephrology
Volume36
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • Graft loss
  • Kidney transplantation
  • Mortality
  • Self-rated health
  • QUALITY-OF-LIFE
  • STAGE RENAL-DISEASE
  • SURVIVAL
  • DIALYSIS
  • COHORT
  • ASSOCIATION
  • RECIPIENTS
  • REJECTION
  • QUESTION
  • OUTCOMES

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