Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements

Ernst Th. Scholten; Bartjan de Hoop; Colin Jacobs; Saskia van Amelsvoort-van de Vorst; Rob J. van Klaveren; Matthijs Oudkerk; Rozemarijn Vliegenthart; Harry J. de Koning; Carlijn M. van der Aalst; Willem Th M. Mali; Hester A. Gietema; Mathias Prokop; Bram van Ginneken; Pim A. de Jong

doi:10.1371/journal.pone.0080249

Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements

Ernst Th. Scholten, Bartjan de Hoop, Colin Jacobs, Saskia van Amelsvoort-van de Vorst, Rob J. van Klaveren, Matthijs Oudkerk, Rozemarijn Vliegenthart, Harry J. de Koning, Carlijn M. van der Aalst, Willem Th M. Mali, Hester A. Gietema, Mathias Prokop, Bram van Ginneken, Pim A. de Jong^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Rationale: Accurate measurement of subsolid pulmonary nodules (SSN) is becoming increasingly important in the management of these nodules. SSNs were previously quantified with time-consuming manual measurements. The aim of the present study is to test the feasibility of semi-automatic SSNs measurements and to compare the results to the manual measurements.

Methods: In 33 lung cancer screening participants with 33 SSNs, the nodules were previously quantified by two observers manually. In the present study two observers quantified these nodules by using semi-automated nodule volumetry software. Nodules were quantified for effective diameter, volume and mass. The manual and semi-automatic measurements were compared using Bland-Altman plots and paired T tests. Observer agreement was calculated as an intraclass correlation coefficient. Data are presented as mean (SD).

Results: Semi-automated measurements were feasible in all 33 nodules. Nodule diameter, volume and mass were 11.2 (3.3) mm, 935 (691) ml and 379 (311) milligrams for observer 1 and 11.1 (3.7) mm, 986 (797) ml and 399 (344) milligrams for observer 2, respectively. Agreement between observers and within observer 1 for the semi-automatic measurements was good with an intraclass correlation coefficient >0.89. For observer 1 and observer 2, measured diameter was 8.8% and 10.3% larger (p

Conclusion: Semi-automated measurement of the diameter, volume and mass of SSNs is feasible with good observer agreement. Semi-automated measurement makes quantification of mass and volume feasible in daily practice.

Original language	English
Article number	e80249
Number of pages	5
Journal	PLoS ONE
Volume	8
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0080249
Publication status	Published - 21-Nov-2013

Keywords

GROUND-GLASS NODULES
FLEISCHNER-SOCIETY
CT
VOLUMETRY
MANAGEMENT
SEGMENTATION
OPACITY
GROWTH
MASS

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Scholten, E. T., de Hoop, B., Jacobs, C., van Amelsvoort-van de Vorst, S., van Klaveren, R. J., Oudkerk, M., Vliegenthart, R., de Koning, H. J., van der Aalst, C. M., Mali, W. T. M., Gietema, H. A., Prokop, M., van Ginneken, B., & de Jong, P. A. (2013). Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements. PLoS ONE, 8(11), Article e80249. https://doi.org/10.1371/journal.pone.0080249

@article{9416ab39ace943b6aff4bc5277c0b931,

title = "Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements",

abstract = "Rationale: Accurate measurement of subsolid pulmonary nodules (SSN) is becoming increasingly important in the management of these nodules. SSNs were previously quantified with time-consuming manual measurements. The aim of the present study is to test the feasibility of semi-automatic SSNs measurements and to compare the results to the manual measurements.Methods: In 33 lung cancer screening participants with 33 SSNs, the nodules were previously quantified by two observers manually. In the present study two observers quantified these nodules by using semi-automated nodule volumetry software. Nodules were quantified for effective diameter, volume and mass. The manual and semi-automatic measurements were compared using Bland-Altman plots and paired T tests. Observer agreement was calculated as an intraclass correlation coefficient. Data are presented as mean (SD).Results: Semi-automated measurements were feasible in all 33 nodules. Nodule diameter, volume and mass were 11.2 (3.3) mm, 935 (691) ml and 379 (311) milligrams for observer 1 and 11.1 (3.7) mm, 986 (797) ml and 399 (344) milligrams for observer 2, respectively. Agreement between observers and within observer 1 for the semi-automatic measurements was good with an intraclass correlation coefficient >0.89. For observer 1 and observer 2, measured diameter was 8.8% and 10.3% larger (pConclusion: Semi-automated measurement of the diameter, volume and mass of SSNs is feasible with good observer agreement. Semi-automated measurement makes quantification of mass and volume feasible in daily practice.",

keywords = "GROUND-GLASS NODULES, FLEISCHNER-SOCIETY, CT, VOLUMETRY, MANAGEMENT, SEGMENTATION, OPACITY, GROWTH, MASS",

author = "Scholten, {Ernst Th.} and {de Hoop}, Bartjan and Colin Jacobs and {van Amelsvoort-van de Vorst}, Saskia and {van Klaveren}, {Rob J.} and Matthijs Oudkerk and Rozemarijn Vliegenthart and {de Koning}, {Harry J.} and {van der Aalst}, {Carlijn M.} and Mali, {Willem Th M.} and Gietema, {Hester A.} and Mathias Prokop and {van Ginneken}, Bram and {de Jong}, {Pim A.}",

year = "2013",

month = nov,

day = "21",

doi = "10.1371/journal.pone.0080249",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "PUBLIC LIBRARY SCIENCE",

number = "11",

}

Scholten, ET, de Hoop, B, Jacobs, C, van Amelsvoort-van de Vorst, S, van Klaveren, RJ, Oudkerk, M , Vliegenthart, R, de Koning, HJ, van der Aalst, CM, Mali, WTM, Gietema, HA, Prokop, M, van Ginneken, B & de Jong, PA 2013, 'Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements', PLoS ONE, vol. 8, no. 11, e80249. https://doi.org/10.1371/journal.pone.0080249

TY - JOUR

T1 - Semi-Automatic Quantification of Subsolid Pulmonary Nodules

T2 - Comparison with Manual Measurements

AU - Scholten, Ernst Th.

AU - de Hoop, Bartjan

AU - Jacobs, Colin

AU - van Amelsvoort-van de Vorst, Saskia

AU - van Klaveren, Rob J.

AU - Oudkerk, Matthijs

AU - Vliegenthart, Rozemarijn

AU - de Koning, Harry J.

AU - van der Aalst, Carlijn M.

AU - Mali, Willem Th M.

AU - Gietema, Hester A.

AU - Prokop, Mathias

AU - van Ginneken, Bram

AU - de Jong, Pim A.

PY - 2013/11/21

Y1 - 2013/11/21

N2 - Rationale: Accurate measurement of subsolid pulmonary nodules (SSN) is becoming increasingly important in the management of these nodules. SSNs were previously quantified with time-consuming manual measurements. The aim of the present study is to test the feasibility of semi-automatic SSNs measurements and to compare the results to the manual measurements.Methods: In 33 lung cancer screening participants with 33 SSNs, the nodules were previously quantified by two observers manually. In the present study two observers quantified these nodules by using semi-automated nodule volumetry software. Nodules were quantified for effective diameter, volume and mass. The manual and semi-automatic measurements were compared using Bland-Altman plots and paired T tests. Observer agreement was calculated as an intraclass correlation coefficient. Data are presented as mean (SD).Results: Semi-automated measurements were feasible in all 33 nodules. Nodule diameter, volume and mass were 11.2 (3.3) mm, 935 (691) ml and 379 (311) milligrams for observer 1 and 11.1 (3.7) mm, 986 (797) ml and 399 (344) milligrams for observer 2, respectively. Agreement between observers and within observer 1 for the semi-automatic measurements was good with an intraclass correlation coefficient >0.89. For observer 1 and observer 2, measured diameter was 8.8% and 10.3% larger (pConclusion: Semi-automated measurement of the diameter, volume and mass of SSNs is feasible with good observer agreement. Semi-automated measurement makes quantification of mass and volume feasible in daily practice.

AB - Rationale: Accurate measurement of subsolid pulmonary nodules (SSN) is becoming increasingly important in the management of these nodules. SSNs were previously quantified with time-consuming manual measurements. The aim of the present study is to test the feasibility of semi-automatic SSNs measurements and to compare the results to the manual measurements.Methods: In 33 lung cancer screening participants with 33 SSNs, the nodules were previously quantified by two observers manually. In the present study two observers quantified these nodules by using semi-automated nodule volumetry software. Nodules were quantified for effective diameter, volume and mass. The manual and semi-automatic measurements were compared using Bland-Altman plots and paired T tests. Observer agreement was calculated as an intraclass correlation coefficient. Data are presented as mean (SD).Results: Semi-automated measurements were feasible in all 33 nodules. Nodule diameter, volume and mass were 11.2 (3.3) mm, 935 (691) ml and 379 (311) milligrams for observer 1 and 11.1 (3.7) mm, 986 (797) ml and 399 (344) milligrams for observer 2, respectively. Agreement between observers and within observer 1 for the semi-automatic measurements was good with an intraclass correlation coefficient >0.89. For observer 1 and observer 2, measured diameter was 8.8% and 10.3% larger (pConclusion: Semi-automated measurement of the diameter, volume and mass of SSNs is feasible with good observer agreement. Semi-automated measurement makes quantification of mass and volume feasible in daily practice.

KW - GROUND-GLASS NODULES

KW - FLEISCHNER-SOCIETY

KW - CT

KW - VOLUMETRY

KW - MANAGEMENT

KW - SEGMENTATION

KW - OPACITY

KW - GROWTH

KW - MASS

U2 - 10.1371/journal.pone.0080249

DO - 10.1371/journal.pone.0080249

M3 - Article

C2 - 24278264

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 11

M1 - e80249

ER -

Semi-Automatic Quantification of Subsolid Pulmonary Nodules: Comparison with Manual Measurements

Abstract

Keywords

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