Senescence of the adaptive immune system in health and aging-associated autoimmune disease

Kornelis Stephan Mario van der Geest

Senescence of the adaptive immune system in health and aging-associated autoimmune disease

Kornelis Stephan Mario van der Geest

Translational Immunology Groningen (TRIGR)

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

Aging of the immune system may contribute to the development of aging-associated autoimmune diseases, such as giant cell arteritis, polymyalgia rheumatica and rheumatoid arthritis. The aim of this thesis was to identify aging-dependent changes of the adaptive immune system that promote autoimmunity in the elderly. The first chapters of this thesis describe changes of the adaptive immune system occurring during healthy aging (chapters 2 to 6). Furthermore, we link maintenance of particular T and B cell populations to risk factors for aging-associated autoimmune diseases and development of circulating autoantibodies (chapters 2 and 6). The final chapters of this thesis focus on changes of the adaptive immune system in patients with aging-associated autoimmune diseases, i.e. giant cell arteritis and polymyalgia rheumatica (chapters 7 to 9). Furthermore, the diagnostic potential of cellular and soluble immune parameters is explored in the latter two diseases (chapters 8 and 9).

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Boots, Mieke, Supervisor Brouwer, Liesbeth, Co-supervisor Abdulahad, Wayel, Co-supervisor Kroesen, Bart Jan, Co-supervisor
Award date	18-Nov-2015
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-90-367-8122-0
Electronic ISBNs	978-90-367-8121-3
Publication status	Published - 2015

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Title_and_contentsFinal publisher's version, 521 KB
Chapter_1Final publisher's version, 927 KB
Chapter_2Final publisher's version, 1.11 MB
Chapter_3Final publisher's version, 2.55 MB
Chapter_4Final publisher's version, 3.72 MB
Chapter_5Final publisher's version, 2.22 MB
Chapter_6Final publisher's version, 1.3 MB
Chapter_7Final publisher's version, 2.22 MB
Chapter_8Final publisher's version, 1.32 MB
Chapter_9Final publisher's version, 1.51 MB
Chapter_10Final publisher's version, 1.93 MB
Chapter_11Final publisher's version, 357 KB
Complete_thesisFinal publisher's version, 15.2 MB
PropositionsFinal publisher's version, 43.2 KB

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abstract = "Aging of the immune system may contribute to the development of aging-associated autoimmune diseases, such as giant cell arteritis, polymyalgia rheumatica and rheumatoid arthritis. The aim of this thesis was to identify aging-dependent changes of the adaptive immune system that promote autoimmunity in the elderly. The first chapters of this thesis describe changes of the adaptive immune system occurring during healthy aging (chapters 2 to 6). Furthermore, we link maintenance of particular T and B cell populations to risk factors for aging-associated autoimmune diseases and development of circulating autoantibodies (chapters 2 and 6). The final chapters of this thesis focus on changes of the adaptive immune system in patients with aging-associated autoimmune diseases, i.e. giant cell arteritis and polymyalgia rheumatica (chapters 7 to 9). Furthermore, the diagnostic potential of cellular and soluble immune parameters is explored in the latter two diseases (chapters 8 and 9).",

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AB - Aging of the immune system may contribute to the development of aging-associated autoimmune diseases, such as giant cell arteritis, polymyalgia rheumatica and rheumatoid arthritis. The aim of this thesis was to identify aging-dependent changes of the adaptive immune system that promote autoimmunity in the elderly. The first chapters of this thesis describe changes of the adaptive immune system occurring during healthy aging (chapters 2 to 6). Furthermore, we link maintenance of particular T and B cell populations to risk factors for aging-associated autoimmune diseases and development of circulating autoantibodies (chapters 2 and 6). The final chapters of this thesis focus on changes of the adaptive immune system in patients with aging-associated autoimmune diseases, i.e. giant cell arteritis and polymyalgia rheumatica (chapters 7 to 9). Furthermore, the diagnostic potential of cellular and soluble immune parameters is explored in the latter two diseases (chapters 8 and 9).

M3 - Thesis fully internal (DIV)

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PB - University of Groningen

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ER -