Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine

Xiaoyan Wang, Hendrika Bootsma, Frans Kroese, Gerard Dijkstra, Sarah Pringle*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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We demonstrate presence of senescent (p16(+), p21(+)) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn's disease. This may explain why Crohn's lesions recur in the same places.

Original languageEnglish
Article numberizz295
Pages (from-to)E8-E9
Number of pages2
JournalInflammatory Bowel Diseases
Issue number2
Publication statusPublished - 6-Jan-2020


  • Cellular Senescence
  • Crohn Disease/pathology
  • Humans
  • Intestine, Small/pathology
  • Stem Cells/pathology

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