Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine

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Abstract

We demonstrate presence of senescent (p16(+), p21(+)) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn's disease. This may explain why Crohn's lesions recur in the same places.

Original languageEnglish
Article numberizz295
Pages (from-to)E8-E9
Number of pages2
JournalInflammatory Bowel Diseases
Volume26
Issue number2
DOIs
Publication statusPublished - 6-Jan-2020

Keywords

  • Cellular Senescence
  • Crohn Disease/pathology
  • Humans
  • Intestine, Small/pathology
  • Stem Cells/pathology

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