Sentinel node biopsy in vulvar cancer: Implications for staging

M. H. M. Oonk*, H. Hollema, A. G. J. van der Zee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

In 2008, the first Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V) showed that omission of inguinofemoral lymphadenectomy is safe in patients with early-stage vulvar cancer and a negative sentinel node and it simultaneously decreases treatment-related morbidity. An important part of the sentinel node procedure is pathologic ultrastaging of the removed sentinel nodes. Subsequently, since the introduction of this procedure in the standard care of patients with early-stage vulvar cancer, more and smaller inguinofemoral lymph node metastases have been diagnosed. The clinical consequences of these micrometastases are not clear yet. With increasing size of the sentinel node metastasis, chances of non-sentinel node metastases increase and those of survival decrease. The size of lymph node metastases is included in the latest staging system for vulvar cancer, however at this moment without clinical implications. Furthermore, a separate category for micrometastases is not incorporated yet. More research is needed to determine the clinical consequences of the size of (sentinel) lymph node metastases. (C) 2015 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)812-821
Number of pages10
JournalBest practice & research in clinical obstetrics & gynaecology
Volume29
Issue number6
DOIs
Publication statusPublished - Aug-2015

Keywords

  • vulvar cancer
  • sentinel node procedure
  • lymph node metastasis
  • micrometastasis
  • staging
  • SQUAMOUS-CELL CARCINOMA
  • GYNECOLOGIC-ONCOLOGY-GROUP
  • SEPARATE GROIN INCISIONS
  • LYMPH-NODE
  • PROGNOSTIC-SIGNIFICANCE
  • RADIATION-THERAPY
  • FOLLOW-UP
  • BLUE-DYE
  • IDENTIFICATION
  • MULTICENTER

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