Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

B M de Jong; J M Ruijter; T P Van der Woude; M Mirmiran; E A van Royen

doi:10.1016/0883-2897(89)90157-8

Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

B M de Jong, J M Ruijter, T P Van der Woude, M Mirmiran, E A van Royen

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Abstract

The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings.

Original language	English
Pages (from-to)	753-757
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/0883-2897(89)90157-8
Publication status	Published - 1989
Externally published	Yes

Keywords

Amphetamines
Animals
Brain
Iodine Radioisotopes
Iofetamine
Male
Rats
Rats, Inbred Strains
Receptors, Serotonin

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title = "Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo",

abstract = "The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings.",

keywords = "Amphetamines, Animals, Brain, Iodine Radioisotopes, Iofetamine, Male, Rats, Rats, Inbred Strains, Receptors, Serotonin",

author = "{de Jong}, {B M} and Ruijter, {J M} and {Van der Woude}, {T P} and M Mirmiran and {van Royen}, {E A}",

year = "1989",

doi = "10.1016/0883-2897(89)90157-8",

language = "English",

volume = "16",

pages = "753--757",

journal = "Nuclear Medicine and Biology",

issn = "0883-2897",

publisher = "ELSEVIER SCIENCE INC",

number = "8",

}

TY - JOUR

T1 - Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

AU - de Jong, B M

AU - Ruijter, J M

AU - Van der Woude, T P

AU - Mirmiran, M

AU - van Royen, E A

PY - 1989

Y1 - 1989

N2 - The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings.

AB - The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings.

KW - Amphetamines

KW - Animals

KW - Brain

KW - Iodine Radioisotopes

KW - Iofetamine

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Receptors, Serotonin

U2 - 10.1016/0883-2897(89)90157-8

DO - 10.1016/0883-2897(89)90157-8

M3 - Article

C2 - 2621111

SN - 0883-2897

VL - 16

SP - 753

EP - 757

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 8

ER -

Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

Abstract

Keywords

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