Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women: A Study from Indonesia

Muhammad Ilham Aldika Akbar; Firas Farisi Alkaff; Alfonsus Adrian Hadikusumo Harsono; Dwi Krisna Imawan; Yudha Klahan; Cardo Adrian Nugraha; Tannicko Octora; Michael Jonatan

doi:10.7860/JCDR/2019/39924.12667

Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women: A Study from Indonesia

Muhammad Ilham Aldika Akbar, Firas Farisi Alkaff^*, Alfonsus Adrian Hadikusumo Harsono, Dwi Krisna Imawan, Yudha Klahan, Cardo Adrian Nugraha, Tannicko Octora, Michael Jonatan

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Introduction: Pre-eclampsia is one of the most common causes of fetomaternal morbidity and mortality worldwide. This disorder is categorised into Early Onset Pre-eclampsia (EOPE) and Late-Onset Pre-eclampsia (LOPE). EOPE is usually accompanied by severe complications for both the mother and fetus, while LOPE is accompanied by relatively mild fetomaternal complications. Although the pathogenesis of EOPE is not yet fully elucidated, recent studies indicate that serum calcium and 25 Hydroxy Vitamin D (25(OH)D) levels may play a role in its pathogenesis.

Aim: To find out the relationship of calcium and 25(OH)D serum levels in pregnant women with normal pregnancy and with EOPE in Indonesia.

Materials and Methods: This study was a case-control study, conducted in Dr. Soetomo General Hospital from July to October 2017. A total of 36 women with EOPE and 64 women with normal pregnancy were included in this study. Inclusion criteria were pregnant women in 2nd or 3rd-trimester with BMI > 18 kg/m(2). Blood sample analysis was done to measure serum calcium and 25(OH)D level. Data were expressed as Mean +/- Standard Deviation. Data distribution was analysed using Shappiro-Wilk test. Comparison of serum calcium and 25(OH)D level between groups was analysed using Independent t-test. Correlation between serum calcium and 25(OH)D level was analysed using Pearson's correlation test. The p-value of

Results: There was a significant difference in serum calcium level between case and control group (8.294 +/- 0.725 vs 8.670 +/- 0.405 mg/dL; p=0.006). In 25(OH)D level, there was no difference between both groups (16.128 +/- 7.5463 vs 17.325 +/- 6.4992 ng/mL; p=0.406). No correlation was found between calcium and 25(OH)D level (r=0.165; p=0.101).

Conclusion: Calcium deficiency plays a role in the incidence of EOPE among pregnant women in Indonesia. The actual role of calcium deficiency in EOPE needs further investigation.

Original language	English
Pages (from-to)	QC04-QC07
Number of pages	4
Journal	Journal of clinical and diagnostic research
Volume	13
Issue number	3
DOIs	https://doi.org/10.7860/JCDR/2019/39924.12667
Publication status	Published - 1-Mar-2019

Keywords

Calcium deficiency
Early-Onset Preeclampsia
Fetomaternal complications
Pregnant women
25(OH)D Deficiency
D DEFICIENCY
MAGNESIUM
ECLAMPSIA
RISK

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@article{e2d0ff81b5174bb4857a309f226d4521,

title = "Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women: A Study from Indonesia",

abstract = "Introduction: Pre-eclampsia is one of the most common causes of fetomaternal morbidity and mortality worldwide. This disorder is categorised into Early Onset Pre-eclampsia (EOPE) and Late-Onset Pre-eclampsia (LOPE). EOPE is usually accompanied by severe complications for both the mother and fetus, while LOPE is accompanied by relatively mild fetomaternal complications. Although the pathogenesis of EOPE is not yet fully elucidated, recent studies indicate that serum calcium and 25 Hydroxy Vitamin D (25(OH)D) levels may play a role in its pathogenesis.Aim: To find out the relationship of calcium and 25(OH)D serum levels in pregnant women with normal pregnancy and with EOPE in Indonesia.Materials and Methods: This study was a case-control study, conducted in Dr. Soetomo General Hospital from July to October 2017. A total of 36 women with EOPE and 64 women with normal pregnancy were included in this study. Inclusion criteria were pregnant women in 2nd or 3rd-trimester with BMI > 18 kg/m(2). Blood sample analysis was done to measure serum calcium and 25(OH)D level. Data were expressed as Mean +/- Standard Deviation. Data distribution was analysed using Shappiro-Wilk test. Comparison of serum calcium and 25(OH)D level between groups was analysed using Independent t-test. Correlation between serum calcium and 25(OH)D level was analysed using Pearson's correlation test. The p-value ofResults: There was a significant difference in serum calcium level between case and control group (8.294 +/- 0.725 vs 8.670 +/- 0.405 mg/dL; p=0.006). In 25(OH)D level, there was no difference between both groups (16.128 +/- 7.5463 vs 17.325 +/- 6.4992 ng/mL; p=0.406). No correlation was found between calcium and 25(OH)D level (r=0.165; p=0.101).Conclusion: Calcium deficiency plays a role in the incidence of EOPE among pregnant women in Indonesia. The actual role of calcium deficiency in EOPE needs further investigation.",

keywords = "Calcium deficiency, Early-Onset Preeclampsia, Fetomaternal complications, Pregnant women, 25(OH)D Deficiency, D DEFICIENCY, MAGNESIUM, ECLAMPSIA, RISK",

author = "Akbar, {Muhammad Ilham Aldika} and Alkaff, {Firas Farisi} and Harsono, {Alfonsus Adrian Hadikusumo} and Imawan, {Dwi Krisna} and Yudha Klahan and Nugraha, {Cardo Adrian} and Tannicko Octora and Michael Jonatan",

year = "2019",

month = mar,

day = "1",

doi = "10.7860/JCDR/2019/39924.12667",

language = "English",

volume = "13",

pages = "QC04--QC07",

journal = "Journal of clinical and diagnostic research",

issn = "2249-782X",

publisher = "PREMCHAND SHANTIDEVI RESEARCH FOUNDATION",

number = "3",

}

Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women: A Study from Indonesia. / Akbar, Muhammad Ilham Aldika; Alkaff, Firas Farisi; Harsono, Alfonsus Adrian Hadikusumo et al.
In: Journal of clinical and diagnostic research, Vol. 13, No. 3, 01.03.2019, p. QC04-QC07.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women

T2 - A Study from Indonesia

AU - Akbar, Muhammad Ilham Aldika

AU - Alkaff, Firas Farisi

AU - Harsono, Alfonsus Adrian Hadikusumo

AU - Imawan, Dwi Krisna

AU - Klahan, Yudha

AU - Nugraha, Cardo Adrian

AU - Octora, Tannicko

AU - Jonatan, Michael

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Introduction: Pre-eclampsia is one of the most common causes of fetomaternal morbidity and mortality worldwide. This disorder is categorised into Early Onset Pre-eclampsia (EOPE) and Late-Onset Pre-eclampsia (LOPE). EOPE is usually accompanied by severe complications for both the mother and fetus, while LOPE is accompanied by relatively mild fetomaternal complications. Although the pathogenesis of EOPE is not yet fully elucidated, recent studies indicate that serum calcium and 25 Hydroxy Vitamin D (25(OH)D) levels may play a role in its pathogenesis.Aim: To find out the relationship of calcium and 25(OH)D serum levels in pregnant women with normal pregnancy and with EOPE in Indonesia.Materials and Methods: This study was a case-control study, conducted in Dr. Soetomo General Hospital from July to October 2017. A total of 36 women with EOPE and 64 women with normal pregnancy were included in this study. Inclusion criteria were pregnant women in 2nd or 3rd-trimester with BMI > 18 kg/m(2). Blood sample analysis was done to measure serum calcium and 25(OH)D level. Data were expressed as Mean +/- Standard Deviation. Data distribution was analysed using Shappiro-Wilk test. Comparison of serum calcium and 25(OH)D level between groups was analysed using Independent t-test. Correlation between serum calcium and 25(OH)D level was analysed using Pearson's correlation test. The p-value ofResults: There was a significant difference in serum calcium level between case and control group (8.294 +/- 0.725 vs 8.670 +/- 0.405 mg/dL; p=0.006). In 25(OH)D level, there was no difference between both groups (16.128 +/- 7.5463 vs 17.325 +/- 6.4992 ng/mL; p=0.406). No correlation was found between calcium and 25(OH)D level (r=0.165; p=0.101).Conclusion: Calcium deficiency plays a role in the incidence of EOPE among pregnant women in Indonesia. The actual role of calcium deficiency in EOPE needs further investigation.

AB - Introduction: Pre-eclampsia is one of the most common causes of fetomaternal morbidity and mortality worldwide. This disorder is categorised into Early Onset Pre-eclampsia (EOPE) and Late-Onset Pre-eclampsia (LOPE). EOPE is usually accompanied by severe complications for both the mother and fetus, while LOPE is accompanied by relatively mild fetomaternal complications. Although the pathogenesis of EOPE is not yet fully elucidated, recent studies indicate that serum calcium and 25 Hydroxy Vitamin D (25(OH)D) levels may play a role in its pathogenesis.Aim: To find out the relationship of calcium and 25(OH)D serum levels in pregnant women with normal pregnancy and with EOPE in Indonesia.Materials and Methods: This study was a case-control study, conducted in Dr. Soetomo General Hospital from July to October 2017. A total of 36 women with EOPE and 64 women with normal pregnancy were included in this study. Inclusion criteria were pregnant women in 2nd or 3rd-trimester with BMI > 18 kg/m(2). Blood sample analysis was done to measure serum calcium and 25(OH)D level. Data were expressed as Mean +/- Standard Deviation. Data distribution was analysed using Shappiro-Wilk test. Comparison of serum calcium and 25(OH)D level between groups was analysed using Independent t-test. Correlation between serum calcium and 25(OH)D level was analysed using Pearson's correlation test. The p-value ofResults: There was a significant difference in serum calcium level between case and control group (8.294 +/- 0.725 vs 8.670 +/- 0.405 mg/dL; p=0.006). In 25(OH)D level, there was no difference between both groups (16.128 +/- 7.5463 vs 17.325 +/- 6.4992 ng/mL; p=0.406). No correlation was found between calcium and 25(OH)D level (r=0.165; p=0.101).Conclusion: Calcium deficiency plays a role in the incidence of EOPE among pregnant women in Indonesia. The actual role of calcium deficiency in EOPE needs further investigation.

KW - Calcium deficiency

KW - Early-Onset Preeclampsia

KW - Fetomaternal complications

KW - Pregnant women

KW - 25(OH)D Deficiency

KW - D DEFICIENCY

KW - MAGNESIUM

KW - ECLAMPSIA

KW - RISK

U2 - 10.7860/JCDR/2019/39924.12667

DO - 10.7860/JCDR/2019/39924.12667

M3 - Article

SN - 2249-782X

VL - 13

SP - QC04-QC07

JO - Journal of clinical and diagnostic research

JF - Journal of clinical and diagnostic research

IS - 3

ER -

Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women: A Study from Indonesia

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