TY - JOUR
T1 - Serum carnosinase 1, an early indicator for incident microalbuminuria in type 1 diabetes
AU - Qiu, Jiedong
AU - Yard, Benito A.
AU - Krämer, Bernhard K.
AU - Bilo, Henk J.G.
AU - Kannt, Aimo
AU - van Goor, Harry
AU - van Dijk, Peter R.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/6
Y1 - 2024/6
N2 - AIMS: Carnosinase (CN1) polymorphisms have been linked to diabetic kidney disease (DKD), as CN1 degrades dipeptides which scavenge oxidative metabolites and prevent the formation of advanced glycation end-products. In this work, we studied the association between serum CN1, the systemic redox status and long-term renal outcome in type 1 diabetes.METHODS: Serum CN1 was measured in a prospective type 1 diabetes cohort (
n = 218) with a 16-year follow-up. A total of 218 patients treated at the Diabetes Outpatient Clinic of the Weezenlanden Hospital (nowadays Isala Hospital, Zwolle, The Netherlands) were included in this analysis. We assessed whether serum CN1 was associated with renal function and development of DKD as well as other diabetic complications.
RESULTS: At baseline, age, systemic redox status and N-terminal pro brain-natriuretic peptide (NT-proBNP) were associated with serum CN1 concentration (
p < 0.05). During follow-up, CN1 concentration in the middle tertile was associated with less incident microalbuminuria (odds ratio = 0.194, 95% C.I.: 0.049-0.772,
p = 0.02) after adjustment for age, systemic redox status, NT-proBNP and sex.
DISCUSSION: Serum CN1 could predict incident microalbuminuria and may be used as a novel parameter to identify patients at risk for DKD.
AB - AIMS: Carnosinase (CN1) polymorphisms have been linked to diabetic kidney disease (DKD), as CN1 degrades dipeptides which scavenge oxidative metabolites and prevent the formation of advanced glycation end-products. In this work, we studied the association between serum CN1, the systemic redox status and long-term renal outcome in type 1 diabetes.METHODS: Serum CN1 was measured in a prospective type 1 diabetes cohort (
n = 218) with a 16-year follow-up. A total of 218 patients treated at the Diabetes Outpatient Clinic of the Weezenlanden Hospital (nowadays Isala Hospital, Zwolle, The Netherlands) were included in this analysis. We assessed whether serum CN1 was associated with renal function and development of DKD as well as other diabetic complications.
RESULTS: At baseline, age, systemic redox status and N-terminal pro brain-natriuretic peptide (NT-proBNP) were associated with serum CN1 concentration (
p < 0.05). During follow-up, CN1 concentration in the middle tertile was associated with less incident microalbuminuria (odds ratio = 0.194, 95% C.I.: 0.049-0.772,
p = 0.02) after adjustment for age, systemic redox status, NT-proBNP and sex.
DISCUSSION: Serum CN1 could predict incident microalbuminuria and may be used as a novel parameter to identify patients at risk for DKD.
KW - Carnosine
KW - Diabetic nephropathy
KW - Histidine-dipeptidase
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85189324304&partnerID=8YFLogxK
U2 - 10.1007/s40200-024-01422-6
DO - 10.1007/s40200-024-01422-6
M3 - Article
C2 - 38932803
AN - SCOPUS:85189324304
SN - 2251-6581
VL - 23
SP - 1271
EP - 1277
JO - Journal of diabetes and metabolic disorders
JF - Journal of diabetes and metabolic disorders
IS - 1
ER -