Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort

Jiedong Qiu; Benito A Yard; Bernhard K Krämer; Harry van Goor; Peter R van Dijk; Aimo Kannt

doi:10.3390/biomedicines13020366

Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort

Jiedong Qiu, Benito A Yard, Bernhard K Krämer, Harry van Goor, Peter R van Dijk^*, Aimo Kannt^*

^*Corresponding author for this work

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Abstract

Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans.

Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared.

Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles ( p > 0.05).

Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort.

Original language	English
Article number	366
Number of pages	8
Journal	Biomedicines
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/biomedicines13020366
Publication status	Published - 5-Feb-2025

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title = "Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort",

abstract = " Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans.Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared.Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles ( p > 0.05).Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort. ",

author = "Jiedong Qiu and Yard, {Benito A} and Kr{\"a}mer, {Bernhard K} and {van Goor}, Harry and {van Dijk}, {Peter R} and Aimo Kannt",

year = "2025",

month = feb,

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doi = "10.3390/biomedicines13020366",

language = "English",

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issn = "2227-9059",

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T1 - Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort

AU - Qiu, Jiedong

AU - Yard, Benito A

AU - Krämer, Bernhard K

AU - van Goor, Harry

AU - van Dijk, Peter R

AU - Kannt, Aimo

PY - 2025/2/5

Y1 - 2025/2/5

N2 - Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans.Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared.Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles ( p > 0.05).Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort.

AB - Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans.Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared.Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles ( p > 0.05).Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort.

U2 - 10.3390/biomedicines13020366

DO - 10.3390/biomedicines13020366

M3 - Article

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VL - 13

JO - Biomedicines

JF - Biomedicines

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ER -

Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort

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