Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: A potential role for interleukin 7

Annechien J. A. Lambeck, Anne P. G. Crijns, Ninke Leffers, Wim J. Sluiter, Klaske A. ten Hoor, Mike Braid, Ate G. J. van der Zee, Toos Daemen, Hans W. Nijman*, W. Martin Kast

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)

Abstract

Purpose: To evaluate if serum cytokine levels could be used as diagnostic or prognostic markers in ovarian cancer.

Experimental Design: A cytokine bead array was done to simultaneously analyze 14 cytokines in the sera of 187 ovarian cancer patients with complete clinicopathologic data and follow-up, 45 patients with benign ovarian tumors, and 50 healthy controls. Serum levels of the well-known serum tumor marker CA-125 were routinely measured in all patients.

Results: Serum levels of CA-125, interleukin 6 (IL-6), IL-7, and IL-10 were elevated in ovarian cancer patients compared with patients with benign ovarian tumors. Analyzing the cytokines in combination with CA-125 showed that a combination of IL-7 and CA-125 serum levels could accurately predict 69% of the ovarian cancer patients, without falsely classifying patients with benign pelvic mass. The cytokines IL-6, IL-7, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), and IP-10 and CA-125 were associated with disease-free and overall survival in univariate analysis. In multivariate analysis, IL-7 and IP-10 were independent predictors of overall survival, although after inclusion of the clininopathologic parameters, only stage and residual disease remained as independent predictors of survival.

Conclusions: IL-7 levels were found to be strongly associated with ovarian cancer and could be used in combination with CA-125 to distinguish between malignant and benign ovarian tumors.

Original languageEnglish
Pages (from-to)2385-2391
Number of pages7
JournalClinical Cancer Research
Volume13
Issue number8
DOIs
Publication statusPublished - 15-Apr-2007

Keywords

  • CARCINOMA
  • EXPRESSION
  • IMMUNITY
  • IL-7

Cite this