Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: a potentially useful biomarker of oxidative stress

Jenny Borkent; Magdalini Ioannou; Tessa Folkertsma; Klaas J. Wardenaar; Bartholomeus C. M. Haarman; Harry van Goor; Iris E. C. Sommer; Arno R. Bourgonje

doi:10.1016/j.psychres.2023.115075

Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: a potentially useful biomarker of oxidative stress

Jenny Borkent^*, Magdalini Ioannou, Tessa Folkertsma, Klaas J. Wardenaar, Bartholomeus C. M. Haarman, Harry van Goor, Iris E. C. Sommer, Arno R. Bourgonje

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Schizophrenia spectrum disorders (SSD) have been linked to oxidative stress (OS). Recent findings from our group show that serum free thiols (R-SH, sulfhydryl groups) can function as an accurate biomarker of systemic OS, since they are readily oxidized by reactive species (ROS), thereby serving as potent antioxidants. The aim of this study is to investigate if reduced R-SH levels can be demonstrated in recently diagnosed patients with SSD compared to healthy controls (HC).

In this study, 102 patients with recently diagnosed SSD (< three years), and 42 HC were included. Levels of R-SH were quantified and studied for correlations with age, C-reactive protein (CRP) as proxy of inflammation as well as body mass index (BMI) and total cholesterol as indices of metabolic health.

R-SH levels were significantly lower in patients when compared to HC. When correcting for age the difference was borderline significant (p=0.05). Moreover, R-SH correlated significantly with age (r = -0.29) and CRP (r = -0.29) in patients with SSD, but not in the HC.

R-SH levels are reduced in SSD as compared to HC and correlate negatively with CRP and age in SSD. Future studies are required to further investigate R-SH and its role in SSD.

Original language	English
Article number	115075
Number of pages	7
Journal	Psychiatry Research
Volume	321
Early online date	26-Jan-2023
DOIs	https://doi.org/10.1016/j.psychres.2023.115075
Publication status	Published - Mar-2023

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@article{6edc85406bd04969aa8f2b06403799d4,

title = "Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: a potentially useful biomarker of oxidative stress",

abstract = "Schizophrenia spectrum disorders (SSD) have been linked to oxidative stress (OS). Recent findings from our group show that serum free thiols (R-SH, sulfhydryl groups) can function as an accurate biomarker of systemic OS, since they are readily oxidized by reactive species (ROS), thereby serving as potent antioxidants. The aim of this study is to investigate if reduced R-SH levels can be demonstrated in recently diagnosed patients with SSD compared to healthy controls (HC).In this study, 102 patients with recently diagnosed SSD (< three years), and 42 HC were included. Levels of R-SH were quantified and studied for correlations with age, C-reactive protein (CRP) as proxy of inflammation as well as body mass index (BMI) and total cholesterol as indices of metabolic health.R-SH levels were significantly lower in patients when compared to HC. When correcting for age the difference was borderline significant (p=0.05). Moreover, R-SH correlated significantly with age (r = -0.29) and CRP (r = -0.29) in patients with SSD, but not in the HC.R-SH levels are reduced in SSD as compared to HC and correlate negatively with CRP and age in SSD. Future studies are required to further investigate R-SH and its role in SSD.",

author = "Jenny Borkent and Magdalini Ioannou and Tessa Folkertsma and Wardenaar, {Klaas J.} and Haarman, {Bartholomeus C. M.} and {van Goor}, Harry and Sommer, {Iris E. C.} and Bourgonje, {Arno R.}",

year = "2023",

month = mar,

doi = "10.1016/j.psychres.2023.115075",

language = "English",

volume = "321",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "ELSEVIER IRELAND LTD",

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TY - JOUR

T1 - Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder

T2 - a potentially useful biomarker of oxidative stress

AU - Borkent, Jenny

AU - Ioannou, Magdalini

AU - Folkertsma, Tessa

AU - Wardenaar, Klaas J.

AU - Haarman, Bartholomeus C. M.

AU - van Goor, Harry

AU - Sommer, Iris E. C.

AU - Bourgonje, Arno R.

PY - 2023/3

Y1 - 2023/3

N2 - Schizophrenia spectrum disorders (SSD) have been linked to oxidative stress (OS). Recent findings from our group show that serum free thiols (R-SH, sulfhydryl groups) can function as an accurate biomarker of systemic OS, since they are readily oxidized by reactive species (ROS), thereby serving as potent antioxidants. The aim of this study is to investigate if reduced R-SH levels can be demonstrated in recently diagnosed patients with SSD compared to healthy controls (HC).In this study, 102 patients with recently diagnosed SSD (< three years), and 42 HC were included. Levels of R-SH were quantified and studied for correlations with age, C-reactive protein (CRP) as proxy of inflammation as well as body mass index (BMI) and total cholesterol as indices of metabolic health.R-SH levels were significantly lower in patients when compared to HC. When correcting for age the difference was borderline significant (p=0.05). Moreover, R-SH correlated significantly with age (r = -0.29) and CRP (r = -0.29) in patients with SSD, but not in the HC.R-SH levels are reduced in SSD as compared to HC and correlate negatively with CRP and age in SSD. Future studies are required to further investigate R-SH and its role in SSD.

AB - Schizophrenia spectrum disorders (SSD) have been linked to oxidative stress (OS). Recent findings from our group show that serum free thiols (R-SH, sulfhydryl groups) can function as an accurate biomarker of systemic OS, since they are readily oxidized by reactive species (ROS), thereby serving as potent antioxidants. The aim of this study is to investigate if reduced R-SH levels can be demonstrated in recently diagnosed patients with SSD compared to healthy controls (HC).In this study, 102 patients with recently diagnosed SSD (< three years), and 42 HC were included. Levels of R-SH were quantified and studied for correlations with age, C-reactive protein (CRP) as proxy of inflammation as well as body mass index (BMI) and total cholesterol as indices of metabolic health.R-SH levels were significantly lower in patients when compared to HC. When correcting for age the difference was borderline significant (p=0.05). Moreover, R-SH correlated significantly with age (r = -0.29) and CRP (r = -0.29) in patients with SSD, but not in the HC.R-SH levels are reduced in SSD as compared to HC and correlate negatively with CRP and age in SSD. Future studies are required to further investigate R-SH and its role in SSD.

U2 - 10.1016/j.psychres.2023.115075

DO - 10.1016/j.psychres.2023.115075

M3 - Article

SN - 0165-1781

VL - 321

JO - Psychiatry Research

JF - Psychiatry Research

M1 - 115075

ER -

Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: a potentially useful biomarker of oxidative stress

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