Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection

Janine de Zeeuw; Sridevi Duggirala; Willemien A Nienhuis; K Mohammed Abass; Wilson Tuah; Till F Omansen; Tjip S van der Werf; Ymkje Stienstra

doi:10.4269/ajtmh.12-0599

Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection

Janine de Zeeuw, Sridevi Duggirala, Willemien A Nienhuis, K Mohammed Abass, Wilson Tuah, Till F Omansen, Tjip S van der Werf, Ymkje Stienstra

Microbes in Health and Disease (MHD)

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.

Original language	English
Pages (from-to)	498-500
Number of pages	3
Journal	The American Society of Tropical Medicine and Hygiene
Volume	89
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.12-0599
Publication status	Published - Sept-2013

Keywords

Anti-Bacterial Agents
Buruli Ulcer
Case-Control Studies
Clarithromycin
Female
Humans
Male
Mycobacterium ulcerans
Neopterin
Randomized Controlled Trials as Topic
Time Factors
Treatment Outcome

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title = "Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection",

abstract = "Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.",

keywords = "Anti-Bacterial Agents, Buruli Ulcer, Case-Control Studies, Clarithromycin, Female, Humans, Male, Mycobacterium ulcerans, Neopterin, Randomized Controlled Trials as Topic, Time Factors, Treatment Outcome",

author = "{de Zeeuw}, Janine and Sridevi Duggirala and Nienhuis, {Willemien A} and Abass, {K Mohammed} and Wilson Tuah and Omansen, {Till F} and {van der Werf}, {Tjip S} and Ymkje Stienstra",

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language = "English",

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AU - de Zeeuw, Janine

AU - Duggirala, Sridevi

AU - Nienhuis, Willemien A

AU - Abass, K Mohammed

AU - Tuah, Wilson

AU - Omansen, Till F

AU - van der Werf, Tjip S

AU - Stienstra, Ymkje

PY - 2013/9

Y1 - 2013/9

N2 - Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.

AB - Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.

KW - Anti-Bacterial Agents

KW - Buruli Ulcer

KW - Case-Control Studies

KW - Clarithromycin

KW - Female

KW - Humans

KW - Male

KW - Mycobacterium ulcerans

KW - Neopterin

KW - Randomized Controlled Trials as Topic

KW - Time Factors

KW - Treatment Outcome

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DO - 10.4269/ajtmh.12-0599

M3 - Article

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SN - 1476-1645

VL - 89

SP - 498

EP - 500

JO - The American Society of Tropical Medicine and Hygiene

JF - The American Society of Tropical Medicine and Hygiene

IS - 3

ER -

Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection

Abstract

Keywords

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