Sex differences in clinical characteristics of dry eye disease

Jelle Vehof; Nicole Sillevis Smitt-Kamminga; Simone A. Nibourg; Christopher J. Hammond

doi:10.1016/j.jtos.2018.01.001

Sex differences in clinical characteristics of dry eye disease

Jelle Vehof^*, Nicole Sillevis Smitt-Kamminga, Simone A. Nibourg, Christopher J. Hammond

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

58 Citations (Scopus)

Abstract

Purpose: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs.

Methods: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex. Sex differences in Spearman correlation between symptoms and signs were calculated.

Results: Women had higher total symptom scores than men in both the mild (33.8 vs 24.7, P = .01) and moderate signs groups (38.3 vs 28.0, P

Conclusions: This large clinical study has shown that sex has a large influence on the symptomatology of DED, with significantly higher symptom scores and lower correlation between symptoms and signs in women compared to men. These findings are of importance in clinical practice and in conducting research into DED. (C) 2018 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	242-248
Number of pages	7
Journal	Ocular Surface
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.jtos.2018.01.001
Publication status	Published - Apr-2018

Keywords

Dry eye disease
Epidemiology
Gender
Neuropathic dry eye
Sex
Signs
Symptoms
CHRONIC PAIN SYNDROMES
CORNEAL SENSITIVITY
WORKSHOP 2007
SYMPTOMS
SUBCOMMITTEE
GENDER
CLASSIFICATION
EPIDEMIOLOGY
DISPARITIES
DEFINITION

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title = "Sex differences in clinical characteristics of dry eye disease",

abstract = "Purpose: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs.Methods: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex. Sex differences in Spearman correlation between symptoms and signs were calculated.Results: Women had higher total symptom scores than men in both the mild (33.8 vs 24.7, P = .01) and moderate signs groups (38.3 vs 28.0, PConclusions: This large clinical study has shown that sex has a large influence on the symptomatology of DED, with significantly higher symptom scores and lower correlation between symptoms and signs in women compared to men. These findings are of importance in clinical practice and in conducting research into DED. (C) 2018 Elsevier Inc. All rights reserved.",

keywords = "Dry eye disease, Epidemiology, Gender, Neuropathic dry eye, Sex, Signs, Symptoms, CHRONIC PAIN SYNDROMES, CORNEAL SENSITIVITY, WORKSHOP 2007, SYMPTOMS, SUBCOMMITTEE, GENDER, CLASSIFICATION, EPIDEMIOLOGY, DISPARITIES, DEFINITION",

author = "Jelle Vehof and Smitt-Kamminga, {Nicole Sillevis} and Nibourg, {Simone A.} and Hammond, {Christopher J.}",

year = "2018",

month = apr,

doi = "10.1016/j.jtos.2018.01.001",

language = "English",

volume = "16",

pages = "242--248",

journal = "Ocular Surface",

issn = "1542-0124",

publisher = "ELSEVIER SCIENCE BV",

number = "2",

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TY - JOUR

T1 - Sex differences in clinical characteristics of dry eye disease

AU - Vehof, Jelle

AU - Smitt-Kamminga, Nicole Sillevis

AU - Nibourg, Simone A.

AU - Hammond, Christopher J.

PY - 2018/4

Y1 - 2018/4

N2 - Purpose: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs.Methods: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex. Sex differences in Spearman correlation between symptoms and signs were calculated.Results: Women had higher total symptom scores than men in both the mild (33.8 vs 24.7, P = .01) and moderate signs groups (38.3 vs 28.0, PConclusions: This large clinical study has shown that sex has a large influence on the symptomatology of DED, with significantly higher symptom scores and lower correlation between symptoms and signs in women compared to men. These findings are of importance in clinical practice and in conducting research into DED. (C) 2018 Elsevier Inc. All rights reserved.

AB - Purpose: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs.Methods: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex. Sex differences in Spearman correlation between symptoms and signs were calculated.Results: Women had higher total symptom scores than men in both the mild (33.8 vs 24.7, P = .01) and moderate signs groups (38.3 vs 28.0, PConclusions: This large clinical study has shown that sex has a large influence on the symptomatology of DED, with significantly higher symptom scores and lower correlation between symptoms and signs in women compared to men. These findings are of importance in clinical practice and in conducting research into DED. (C) 2018 Elsevier Inc. All rights reserved.

KW - Dry eye disease

KW - Epidemiology

KW - Gender

KW - Neuropathic dry eye

KW - Sex

KW - Signs

KW - Symptoms

KW - CHRONIC PAIN SYNDROMES

KW - CORNEAL SENSITIVITY

KW - WORKSHOP 2007

KW - SYMPTOMS

KW - SUBCOMMITTEE

KW - GENDER

KW - CLASSIFICATION

KW - EPIDEMIOLOGY

KW - DISPARITIES

KW - DEFINITION

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DO - 10.1016/j.jtos.2018.01.001

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VL - 16

SP - 242

EP - 248

JO - Ocular Surface

JF - Ocular Surface

IS - 2

ER -

Sex differences in clinical characteristics of dry eye disease

Abstract

Keywords

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