Abstract
Downregulation of CD45RB and L-selectin by anti-CD45RB antibody treatment may play an important role in the mechanism of action these antibodies in transplantation and autoimmune animal models. We found that the metalloprotease TACE/ADAM17 is not involved. Therefore, anti-CD45RB may activate another protease to cause the shedding of L-selectin and possibly also CD45RB.
| Original language | English |
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| Title of host publication | IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY |
| Place of Publication | BOLOGNA |
| Publisher | MEDIMOND PUBLISHING CO |
| Pages | 437-440 |
| Number of pages | 4 |
| ISBN (Print) | 88-7587-073-X |
| Publication status | Published - 2004 |
| Event | 12th Annual International Congress of Immunology/4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS) - , Canada Duration: 18-Jul-2004 → 23-Jul-2004 |
Other
| Other | 12th Annual International Congress of Immunology/4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS) |
|---|---|
| Country/Territory | Canada |
| Period | 18/07/2004 → 23/07/2004 |
Keywords
- REJECTION
- CD45RB
- MICE
- ANTIBODY
- CELLS