Abstract
[reaction: see text] A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, and ring-closing metathesis (RCM) is introduced. The corresponding bifunctional isocyanides carboxylic acids bearing a terminal olefin are easy to prepare from the corresponding commercially available starting materials. Advantageously, this strategy allows fast access to a diverse conformational space of natural product-like macrocycles and could thus be of interest in the discovery of novel bioactive agents.
Original language | English |
---|---|
Pages (from-to) | 1047-1050 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 5 |
Issue number | 7 |
Publication status | Published - 2003 |
Keywords
- alkene
- biological factor
- carboxylic acid
- cyanide
- article
- chemical structure
- chemistry
- cyclization
- macromolecule
- synthesis