Short and diverse route toward complex natural product-like macrocycles.

Barbara Beck, Gregor Larbig, Beatrice Mejat, Marina Magnin-Lachaux, Anne Picard, Eberhardt Herdtweck, Alexander Dömling

Research output: Contribution to journalArticleAcademicpeer-review

108 Citations (Scopus)


[reaction: see text] A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, and ring-closing metathesis (RCM) is introduced. The corresponding bifunctional isocyanides carboxylic acids bearing a terminal olefin are easy to prepare from the corresponding commercially available starting materials. Advantageously, this strategy allows fast access to a diverse conformational space of natural product-like macrocycles and could thus be of interest in the discovery of novel bioactive agents.
Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalOrganic letters
Issue number7
Publication statusPublished - 2003


  • alkene
  • biological factor
  • carboxylic acid
  • cyanide
  • article
  • chemical structure
  • chemistry
  • cyclization
  • macromolecule
  • synthesis

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