Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer's Disease

Jhana O. Hendrickx, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R. Y. De Meyer*

*Corresponding author for this work

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Abstract

Given the unprecedented rise in the world's population, the prevalence of prominent age-related disorders, like cardiovascular disease and dementia, will further increase. Recent experimental and epidemiological evidence suggests a mechanistic overlap between cardiovascular disease and dementia with a specific focus on the linkage between arterial stiffness, a strong independent predictor of cardiovascular disease, and/or hypertension with Alzheimer's disease. In the present study, we investigated whether pharmacological induction of arterial stiffness and hypertension with angiotensin II (1 mu g center dot kg(-1)center dot min(-1) for 28 days via an osmotic minipump) impairs the progression of Alzheimer's disease in two mouse models (hAPP23(+/-) and hAPPswe/PSEN1dE9 mice). Our results show increased arterial stiffness in vivo and hypertension in addition to cardiac hypertrophy after angiotensin II treatment. However, visuospatial learning and memory and pathological cerebral amyloid load in both Alzheimer's disease mouse models were not further impaired. It is likely that the 28-day treatment period with angiotensin II was too short to observe additional effects on cognition and cerebral pathology.

Original languageEnglish
Article number2738
Number of pages18
JournalInternational Journal of Molecular Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - 1-Mar-2022

Keywords

  • arterial stiffness
  • hypertension
  • angiotensin II
  • Alzheimer's disease
  • cognition
  • amyloid
  • ANTIHYPERTENSIVE DRUG-THERAPY
  • BLOOD-PRESSURE
  • MOUSE MODEL
  • COGNITIVE DECLINE
  • ASSOCIATION
  • PROGRESSION
  • LOSARTAN
  • ANEURYSM

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