Shutting down the power supply for DNA repair in cancer cells

Marcel A. T. M. van Vugt

doi:10.1083/jcb.201701026

Shutting down the power supply for DNA repair in cancer cells

Marcel A. T. M. van Vugt^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

219 Downloads (Pure)

Abstract

Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

Original language	English
Pages (from-to)	295-297
Number of pages	3
Journal	The Journal of Cell Biology
Volume	216
Issue number	2
DOIs	https://doi.org/10.1083/jcb.201701026
Publication status	Published - Feb-2017

Keywords

PHOSPHOGLYCERATE MUTASE
STRESS
DAMAGE
G2

Access to Document

10.1083/jcb.201701026Licence: CC BY-NC-SA

Shutting down the power supply for DNA repair in cancer cellsFinal publisher's version, 1.1 MBLicence: CC BY-NC-SA

Handle.net

Persistent link

Cite this

@article{a60abe24f2aa42ea83ab0fe4f64b92cb,

title = "Shutting down the power supply for DNA repair in cancer cells",

abstract = "Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.",

keywords = "PHOSPHOGLYCERATE MUTASE, STRESS, DAMAGE, G2",

author = "{van Vugt}, {Marcel A. T. M.}",

year = "2017",

month = feb,

doi = "10.1083/jcb.201701026",

language = "English",

volume = "216",

pages = "295--297",

journal = "The Journal of Cell Biology",

issn = "0021-9525",

publisher = "ROCKEFELLER UNIV PRESS",

number = "2",

}

TY - JOUR

T1 - Shutting down the power supply for DNA repair in cancer cells

AU - van Vugt, Marcel A. T. M.

PY - 2017/2

Y1 - 2017/2

N2 - Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

AB - Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

KW - PHOSPHOGLYCERATE MUTASE

KW - STRESS

KW - DAMAGE

KW - G2

U2 - 10.1083/jcb.201701026

DO - 10.1083/jcb.201701026

M3 - Review article

SN - 0021-9525

VL - 216

SP - 295

EP - 297

JO - The Journal of Cell Biology

JF - The Journal of Cell Biology

IS - 2

ER -

Shutting down the power supply for DNA repair in cancer cells

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this