Simple noninvasive measurement of skin autofluorescence

R Meerwaldt, T Links, R Graaff, SR Thorpe, JW Baynes, J Hartog, R Gans, Andries Smit

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

160 Citations (Scopus)

Abstract

Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.

Original languageEnglish
Title of host publicationMAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
EditorsJW Baynes, VM Monnier, JM Ames, Thorpe
Place of PublicationNEW YORK
PublisherNew York Academy of Sciences
Pages290-298
Number of pages9
ISBN (Print)1-57331-531-1
DOIs
Publication statusPublished - Jun-2005
Event8th International Symposium on the Maillard Reaction - , Seychelles
Duration: 29-Aug-20041-Sept-2004

Publication series

NameANNALS OF THE NEW YORK ACADEMY OF SCIENCES
PublisherNEW YORK ACAD SCIENCES
Volume1043
ISSN (Print)0077-8923

Other

Other8th International Symposium on the Maillard Reaction
Country/TerritorySeychelles
Period29/08/200401/09/2004

Keywords

  • diabetes
  • advanced glycation end products
  • autofluorescence
  • noninvasive
  • complications
  • GLYCATION END-PRODUCTS
  • DEPENDENT DIABETES-MELLITUS
  • OXIDATIVE STRESS
  • COMPLICATIONS
  • FLUORESCENCE
  • AMINOGUANIDINE
  • GLYCOXIDATION
  • ACCUMULATION
  • NEPHROPATHY
  • DISEASE

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