Simple noninvasive measurement of skin autofluorescence

R Meerwaldt; T Links; R Graaff; SR Thorpe; JW Baynes; J Hartog; R Gans; Andries Smit

doi:10.1196/annals.1333.036

Simple noninvasive measurement of skin autofluorescence

R Meerwaldt, T Links, R Graaff, SR Thorpe, JW Baynes, J Hartog, R Gans, Andries Smit

Groningen Kidney Center (GKC)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

165 Citations (Scopus)

Abstract

Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.

Original language	English
Title of host publication	MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
Editors	JW Baynes, VM Monnier, JM Ames, Thorpe
Place of Publication	NEW YORK
Publisher	New York Academy of Sciences
Pages	290-298
Number of pages	9
ISBN (Print)	1-57331-531-1
DOIs	https://doi.org/10.1196/annals.1333.036
Publication status	Published - Jun-2005
Event	8th International Symposium on the Maillard Reaction - , Seychelles Duration: 29-Aug-2004 → 1-Sept-2004

Publication series

Name	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Publisher	NEW YORK ACAD SCIENCES
Volume	1043
ISSN (Print)	0077-8923

Other

Other	8th International Symposium on the Maillard Reaction
Country/Territory	Seychelles
Period	29/08/2004 → 01/09/2004

Keywords

diabetes
advanced glycation end products
autofluorescence
noninvasive
complications
GLYCATION END-PRODUCTS
DEPENDENT DIABETES-MELLITUS
OXIDATIVE STRESS
COMPLICATIONS
FLUORESCENCE
AMINOGUANIDINE
GLYCOXIDATION
ACCUMULATION
NEPHROPATHY
DISEASE

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10.1196/annals.1333.036

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MEERWALDT_et_al-2005-Annals_of_the_New_York_Academy_of_Sciences
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Meerwaldt, R., Links, T., Graaff, R., Thorpe, SR., Baynes, JW., Hartog, J., Gans, R., & Smit, A. (2005). Simple noninvasive measurement of skin autofluorescence. In JW. Baynes, VM. Monnier, JM. Ames, & Thorpe (Eds.), MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE (pp. 290-298). (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Vol. 1043). New York Academy of Sciences. https://doi.org/10.1196/annals.1333.036

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abstract = "Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.",

keywords = "diabetes, advanced glycation end products, autofluorescence, noninvasive, complications, GLYCATION END-PRODUCTS, DEPENDENT DIABETES-MELLITUS, OXIDATIVE STRESS, COMPLICATIONS, FLUORESCENCE, AMINOGUANIDINE, GLYCOXIDATION, ACCUMULATION, NEPHROPATHY, DISEASE",

author = "R Meerwaldt and T Links and R Graaff and SR Thorpe and JW Baynes and J Hartog and R Gans and Andries Smit",

year = "2005",

month = jun,

doi = "10.1196/annals.1333.036",

language = "English",

isbn = "1-57331-531-1",

series = "ANNALS OF THE NEW YORK ACADEMY OF SCIENCES",

publisher = "New York Academy of Sciences",

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editor = "JW Baynes and VM Monnier and JM Ames and Thorpe",

booktitle = "MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE",

note = "8th International Symposium on the Maillard Reaction ; Conference date: 29-08-2004 Through 01-09-2004",

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Meerwaldt, R, Links, T, Graaff, R, Thorpe, SR, Baynes, JW, Hartog, J, Gans, R & Smit, A 2005, Simple noninvasive measurement of skin autofluorescence. in JW Baynes, VM Monnier, JM Ames & Thorpe (eds), MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1043, New York Academy of Sciences, NEW YORK, pp. 290-298, 8th International Symposium on the Maillard Reaction, Seychelles, 29/08/2004. https://doi.org/10.1196/annals.1333.036

Simple noninvasive measurement of skin autofluorescence. / Meerwaldt, R; Links, T; Graaff, R et al.
MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. ed. / JW Baynes; VM Monnier; JM Ames; Thorpe. NEW YORK: New York Academy of Sciences, 2005. p. 290-298 (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Vol. 1043).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Simple noninvasive measurement of skin autofluorescence

AU - Meerwaldt, R

AU - Links, T

AU - Graaff, R

AU - Thorpe, SR

AU - Baynes, JW

AU - Hartog, J

AU - Gans, R

AU - Smit, Andries

PY - 2005/6

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N2 - Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.

AB - Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long-term complications. Because several AGEs exhibit autofluoreseence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen-linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long-term glycemic control and renal function, and preliminary results show correlations with the presence of long-term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE-related long-term complications in diabetes and in other conditions associated with AGE accumulation.

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KW - advanced glycation end products

KW - autofluorescence

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KW - complications

KW - GLYCATION END-PRODUCTS

KW - DEPENDENT DIABETES-MELLITUS

KW - OXIDATIVE STRESS

KW - COMPLICATIONS

KW - FLUORESCENCE

KW - AMINOGUANIDINE

KW - GLYCOXIDATION

KW - ACCUMULATION

KW - NEPHROPATHY

KW - DISEASE

U2 - 10.1196/annals.1333.036

DO - 10.1196/annals.1333.036

M3 - Conference contribution

SN - 1-57331-531-1

T3 - ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

SP - 290

EP - 298

BT - MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE

A2 - Baynes, JW

A2 - Monnier, VM

A2 - Ames, JM

A2 - Thorpe, null

PB - New York Academy of Sciences

CY - NEW YORK

T2 - 8th International Symposium on the Maillard Reaction

Y2 - 29 August 2004 through 1 September 2004

ER -

Meerwaldt R, Links T, Graaff R, Thorpe SR, Baynes JW, Hartog J et al. Simple noninvasive measurement of skin autofluorescence. In Baynes JW, Monnier VM, Ames JM, Thorpe, editors, MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. NEW YORK: New York Academy of Sciences. 2005. p. 290-298. (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES). doi: 10.1196/annals.1333.036

Simple noninvasive measurement of skin autofluorescence

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Keywords

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