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Abstract

Objectives: 5-Aminosalicylic acid (5-ASA) is an important maintenance drug for patients with ulcerative colitis. A proportion of the ingested dose is excreted in the urine. Measuring 5-ASA and its metabolites in urine requires mass spectrometry, which is not widely available for this purpose. Urinary 5-ASA can be measured by colorimetry using the serum salicylic acid assay and is a surrogate marker of recent 5-ASA ingestion. We evaluated whether measuring 5-ASA in first morning voids or in random spot urine samples correctly identifies teenagers with poor adherence to oral 5-ASA.

Methods: Teenagers who were prescribed a current regimen including > 40 mg.kg(-1).day(-1) of 5-ASA were invited to collect their spot urine with various time lapses since their last presumed 5-ASA ingestion. Classification of adherence was based on a composite method that included a patientreported adherence scale and 6-thioguanine levels in erythrocytes.

Results: Teenagers who were classified as "good adherers'' had 66 of 69 (96%; 95% confidence interval 87%-99%) spot urine samples with detectable 5-ASA levels. "Poor adherers'' had 30 of 45 (67%; 95% confidence interval 52%-79%) spot urine samples with undetectable 5-ASA levels. The "good adherers'' with false-negative urine tests were on a once daily dosing regimen and had collected a spot urine sample shortly before the next dosage. Their first morning voids had detectable 5-ASA levels.

Conclusions: Undetectable 5-ASA levels in the first morning void confirms short-term nonadherence to oral 5-ASA.

Original languageEnglish
Pages (from-to)416-419
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume65
Issue number4
DOIs
Publication statusPublished - Oct-2017

Keywords

  • 5-aminosalicylic acid
  • medication adherence
  • mesalamine
  • ulcerative colitis
  • urine
  • CONSENSUS GUIDELINES
  • MANAGEMENT
  • DISEASE

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