Simulating realistic membrane shapes

Weria Pezeshkian, Siewert J. Marrink*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.

Original languageEnglish
Article numberj.ceb.2021.02.009
Pages (from-to)103-111
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume71
Early online date12-Mar-2021
DOIs
Publication statusE-pub ahead of print - 12-Mar-2021

Keywords

  • Membrane curvature
  • Multiscale simulations
  • Organelle shape
  • Mesoscale models
  • Molecular dynamics
  • Cell membranes

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