Simultaneous assembly of the β-lactam and thiazole moiety by a new multicomponent reaction

Jürgen Kolb, Barbara Beck, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)


A novel multicomponent reaction of β-aminothiocarboxylic acids, aldehydes, and 3-dimethylamino-2-isocyanoacylate is described. During the course of this reaction two heterocyclic moieties, a thiazole and a β-lactam ring, are formed simultaneously and under mild conditions. The increase in molecular complexity here is dramatic as 2 C-N, 2 C-S and 1 C-C bonds are formed in a new 'one-pot' multicomponent reaction. © 2002 Published by Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)6897-6901
Number of pages5
JournalTetrahedron Letters
Issue number39
Publication statusPublished - 23-Sep-2002


  • 3 dimethylamino 2 isocyanoacylate
  • aldehyde derivative
  • beta lactam
  • carboxylic acid derivative
  • isocyanic acid derivative
  • thiazole derivative
  • unclassified drug
  • article
  • chemical bond
  • chemical reaction
  • multicomponent reaction
  • ring opening

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