Positive end-expiratory pressure (PEEP) during controlled mechanical ventilation has been shown to reduce the oxygen saturation of hemoglobin in gastric mucosa (μHbO2)1 and splanchnic microvascular blood flow.2 The effects of PEEP on these microcirculatory variables could be separated from the impact of PEEP on systemic circulation and oxygenation: Normalization of cardiac output and oxygen transport capacity, depressed due to reduced preload during ventilation with PEEP, did not restore microvascular blood flow2 nor 1.μHbO2.3 Similarly, in healthy volunteers breathing continuous positive airway pressure (CPAP) reduced tHbO2 despite unchanged systemic hemodynamics and stable systemic oxygen saturation.4 The mechanism for this obvious different response to PEEP and CPAP in systemic and regional intestinal circulation remains unclear.
|Name||ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY|
|Publisher||KLUWER ACADEMIC/PLENUM PUBL|
|Conference||30th Scientific Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT)|
|Period||01/08/2002 → …|