Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

HF Kuipers, Angelika A.C. Rappert, AM Mommaas, ES Van Haastert, P Van der Valk, HWGM Boddeke, KPH Biber, PJ Van den Elsen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

Statin treatment is proposed to be a new potential therapy for multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. The effects of statin treatment on brain cells, however, are hardly understood. We therefore evaluated the effects of simvastatin treatment on the migratory capacity of brain microglial cells, key elements in the pathogenesis of MS. It is shown that exposure of human and murine microglial cells to simvastatin reduced cell surface expression of the chemokine receptors CCR5 and CXCR3. In addition, simvastatin treatment specifically abolished chemokine-induced microglial cell motility, altered actin cytoskeleton distribution, and led to changes in intracellular vesicles. These data clearly show that simvastatin inhibits several immunological properties of microglia, which may provide a rationale for statin treatment in MS. (c) 2005 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalGlia.
Volume53
Issue number2
DOIs
Publication statusPublished - 15-Jan-2006

Keywords

  • statins
  • microglia
  • chemotaxis
  • multiple sclerosis
  • CENTRAL-NERVOUS-SYSTEM
  • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
  • MEMBRANE RAFT MICRODOMAINS
  • HMG-COA REDUCTASE
  • MULTIPLE-SCLEROSIS
  • IN-VITRO
  • BRAIN-TISSUE
  • EXPRESSION
  • LOVASTATIN
  • STATINS

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