Single cell metabolomics

Matthias Heinemann*, Renato Zenobi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Citations (Scopus)
1241 Downloads (Pure)

Abstract

Recent discoveries suggest that cells of a clonal population often display multiple metabolic phenotypes at the same time. Motivated by the success of mass spectrometry (MS) in the investigation of population-level metabolomics, the analytical community has initiated efforts towards MS-based single cell metabolomics to investigate metabolic phenomena that are buried under the population average. Here, we review the current approaches and illustrate their advantages and disadvantages. Because of significant advances in the field, different technologies are now at the verge of generating data that are useful for exploring and investigating metabolic heterogeneity.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume22
Issue number1
DOIs
Publication statusPublished - Feb-2011

Keywords

  • DESORPTION/IONIZATION MASS-SPECTROMETRY
  • STOCHASTIC GENE-EXPRESSION
  • CAPILLARY-ELECTROPHORESIS
  • MICROFLUIDIC DEVICE
  • ESCHERICHIA-COLI
  • METABOLITES
  • YEAST

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