Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

Werna T Uniken Venema; Michiel D Voskuil; Arnau Vich Vila; Gerben van der Vries; Bernadien H Jansen; B Jabri; Klaas Nico Faber; Gerard Dijkstra; Ramnik J Xavier; Cisca Wijmenga; Daniel B Graham; Rinse K Weersma; Eleonora A Festen

doi:10.1053/j.gastro.2018.10.046

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

Werna T Uniken Venema, Michiel D Voskuil, Arnau Vich Vila, Gerben van der Vries, Bernadien H Jansen, B Jabri, Klaas Nico Faber, Gerard Dijkstra, Ramnik J Xavier, Cisca Wijmenga, Daniel B Graham, Rinse K Weersma, Eleonora A Festen

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

240 Downloads (Pure)

Original language	English
Pages (from-to)	812-+
Number of pages	26
Journal	Gastroenterology
Volume	156
Issue number	3
Early online date	1-Nov-2018
DOIs	https://doi.org/10.1053/j.gastro.2018.10.046
Publication status	Published - Feb-2019

Keywords

Inflammatory Bowel Disease
Genome-wide Association Study
Immune Response
Genetics
INFLAMMATORY-BOWEL-DISEASE
GENE-EXPRESSION
RISK
LOCI

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Uniken Venema, W. T., Voskuil, M. D., Vich Vila, A., van der Vries, G., Jansen, B. H., Jabri, B., Faber, K. N., Dijkstra, G., Xavier, R. J., Wijmenga, C., Graham, D. B., Weersma, R. K., & Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046

Uniken Venema, Werna T ; Voskuil, Michiel D ; Vich Vila, Arnau ; van der Vries, Gerben ; Jansen, Bernadien H ; Jabri, B ; Faber, Klaas Nico ; Dijkstra, Gerard ; Xavier, Ramnik J ; Wijmenga, Cisca ; Graham, Daniel B ; Weersma, Rinse K ; Festen, Eleonora A. / Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. In: Gastroenterology. 2019 ; Vol. 156, No. 3. pp. 812-+.

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title = "Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets",

keywords = "Inflammatory Bowel Disease, Genome-wide Association Study, Immune Response, Genetics, INFLAMMATORY-BOWEL-DISEASE, GENE-EXPRESSION, RISK, LOCI",

author = "{Uniken Venema}, {Werna T} and Voskuil, {Michiel D} and {Vich Vila}, Arnau and {van der Vries}, Gerben and Jansen, {Bernadien H} and B Jabri and Faber, {Klaas Nico} and Gerard Dijkstra and Xavier, {Ramnik J} and Cisca Wijmenga and Graham, {Daniel B} and Weersma, {Rinse K} and Festen, {Eleonora A}",

year = "2019",

month = feb,

doi = "10.1053/j.gastro.2018.10.046",

language = "English",

volume = "156",

pages = "812--+",

journal = "Gastroenterology",

issn = "0016-5085",

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Uniken Venema, WT , Voskuil, MD , Vich Vila, A, van der Vries, G, Jansen, BH, Jabri, B, Faber, KN , Dijkstra, G, Xavier, RJ, Wijmenga, C, Graham, DB, Weersma, RK & Festen, EA 2019, 'Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets', Gastroenterology, vol. 156, no. 3, pp. 812-+. https://doi.org/10.1053/j.gastro.2018.10.046

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. / Uniken Venema, Werna T ; Voskuil, Michiel D ; Vich Vila, Arnau; van der Vries, Gerben; Jansen, Bernadien H; Jabri, B; Faber, Klaas Nico ; Dijkstra, Gerard; Xavier, Ramnik J; Wijmenga, Cisca; Graham, Daniel B; Weersma, Rinse K ; Festen, Eleonora A.

In: Gastroenterology, Vol. 156, No. 3, 02.2019, p. 812-+.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

AU - Uniken Venema, Werna T

AU - Voskuil, Michiel D

AU - Vich Vila, Arnau

AU - van der Vries, Gerben

AU - Jansen, Bernadien H

AU - Jabri, B

AU - Faber, Klaas Nico

AU - Dijkstra, Gerard

AU - Xavier, Ramnik J

AU - Wijmenga, Cisca

AU - Graham, Daniel B

AU - Weersma, Rinse K

AU - Festen, Eleonora A

PY - 2019/2

Y1 - 2019/2

KW - Inflammatory Bowel Disease

KW - Genome-wide Association Study

KW - Immune Response

KW - Genetics

KW - INFLAMMATORY-BOWEL-DISEASE

KW - GENE-EXPRESSION

KW - RISK

KW - LOCI

U2 - 10.1053/j.gastro.2018.10.046

DO - 10.1053/j.gastro.2018.10.046

M3 - Article

C2 - 30391472

VL - 156

SP - 812-+

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -