TY - JOUR
T1 - Sinonasal inverted papilloma and predictors of health-related quality of life after endonasal endoscopic surgery
T2 - A prospective cohort study
AU - den Heijer, Marc C.
AU - Joustra, Gonneke E.
AU - Vermeulen, Karin M.
AU - Korsten-Meijer, Astrid G.W.
AU - Feijen, Robert A.
N1 - Publisher Copyright:
© 2024 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.
PY - 2024/7
Y1 - 2024/7
N2 - Objectives: Existing knowledge on health-related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post-operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post-operative trajectory, investigate if pre-operative observations could predict distinct post-operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post-operative HRQoL. Design: Prospective cohort study. Setting: Tertiary referral hospital. Participants: Seventy-four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull-Base Surgery Questionnaire (EES-Q) pre-operatively, and then 2 weeks, 3 months, and 1 year post-operatively. Main Outcome Measures: Linear mixed models analyses were performed to evaluate the overall post-operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre-operative EES-Q score, type of surgery, and post-operative antibiotics) on HRQoL improvement. Results: The total EES-Q score (p <.001) as well as the physical (p <.001), psychological (p =.049), and the social (p =.002) domains significantly improved post-operatively. ASA classification (p =.049), pre-operative EES-Q score (p <.001) and post-operative antibiotics (p =.036) were significant variables. Conclusions: Overall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre-operative EES-Q score, and the administration of post-operative antibiotics were significant predictors for better HRQoL recovery post-operatively. Further research is necessary to confirm these results.
AB - Objectives: Existing knowledge on health-related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post-operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post-operative trajectory, investigate if pre-operative observations could predict distinct post-operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post-operative HRQoL. Design: Prospective cohort study. Setting: Tertiary referral hospital. Participants: Seventy-four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull-Base Surgery Questionnaire (EES-Q) pre-operatively, and then 2 weeks, 3 months, and 1 year post-operatively. Main Outcome Measures: Linear mixed models analyses were performed to evaluate the overall post-operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre-operative EES-Q score, type of surgery, and post-operative antibiotics) on HRQoL improvement. Results: The total EES-Q score (p <.001) as well as the physical (p <.001), psychological (p =.049), and the social (p =.002) domains significantly improved post-operatively. ASA classification (p =.049), pre-operative EES-Q score (p <.001) and post-operative antibiotics (p =.036) were significant variables. Conclusions: Overall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre-operative EES-Q score, and the administration of post-operative antibiotics were significant predictors for better HRQoL recovery post-operatively. Further research is necessary to confirm these results.
KW - EES-Q
KW - health-related quality of life
KW - patient-reported outcome measure
KW - prospective cohort study
KW - sinonasal inverted papilloma
UR - http://www.scopus.com/inward/record.url?scp=85190757341&partnerID=8YFLogxK
U2 - 10.1111/coa.14158
DO - 10.1111/coa.14158
M3 - Article
C2 - 38613400
AN - SCOPUS:85190757341
SN - 1749-4478
VL - 49
SP - 453
EP - 461
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
IS - 4
ER -