Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study

Jamie M Alberga; Arjan Vissink; Anke Korfage; Sebastiaan A H J de Visscher; Max J H Witjes; Johannes A Langendijk; Gerry M Raghoebar

doi:10.1111/odi.14813

Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study

Jamie M Alberga^*, Arjan Vissink, Anke Korfage, Sebastiaan A H J de Visscher, Max J H Witjes, Johannes A Langendijk, Gerry M Raghoebar

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVES: We assessed the radiation dosages (D mean ) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT).

MATERIALS AND METHODS: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific D mean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss.

RESULTS: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a D mean > 40 Gy. Implant loss occurred only in implants with a D mean > 50 Gy.

CONCLUSION: An implant-specific D mean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.

Original language	English
Pages (from-to)	3866-3872
Number of pages	7
Journal	Oral diseases
Volume	30
Issue number	6
Early online date	20-Nov-2023
DOIs	https://doi.org/10.1111/odi.14813
Publication status	Published - Sept-2024

Keywords

dental implants
implant survival
implant-specific dose
Oral cancer
radiotherapy

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10.1111/odi.14813Licence: CC BY-NC-ND

Site-specific radiation dosage and implant survival in oral cancer patients: A cohort studyFinal publisher's version, 427 KBLicence: CC BY-NC-ND

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@article{f8404b45b59e49e4b9548fd8147b4ceb,

title = "Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study",

abstract = "OBJECTIVES: We assessed the radiation dosages (D mean ) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT). MATERIALS AND METHODS: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific D mean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss. RESULTS: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a D mean > 40 Gy. Implant loss occurred only in implants with a D mean > 50 Gy. CONCLUSION: An implant-specific D mean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss. ",

keywords = "dental implants, implant survival, implant-specific dose, Oral cancer, radiotherapy",

author = "Alberga, {Jamie M} and Arjan Vissink and Anke Korfage and {de Visscher}, {Sebastiaan A H J} and Witjes, {Max J H} and Langendijk, {Johannes A} and Raghoebar, {Gerry M}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.",

year = "2024",

month = sep,

doi = "10.1111/odi.14813",

language = "English",

volume = "30",

pages = "3866--3872",

journal = "Oral diseases",

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TY - JOUR

T1 - Site-specific radiation dosage and implant survival in oral cancer patients

T2 - A cohort study

AU - Alberga, Jamie M

AU - Vissink, Arjan

AU - Korfage, Anke

AU - de Visscher, Sebastiaan A H J

AU - Witjes, Max J H

AU - Langendijk, Johannes A

AU - Raghoebar, Gerry M

PY - 2024/9

Y1 - 2024/9

N2 - OBJECTIVES: We assessed the radiation dosages (D mean ) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT). MATERIALS AND METHODS: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific D mean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss. RESULTS: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a D mean > 40 Gy. Implant loss occurred only in implants with a D mean > 50 Gy. CONCLUSION: An implant-specific D mean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.

AB - OBJECTIVES: We assessed the radiation dosages (D mean ) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT). MATERIALS AND METHODS: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific D mean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss. RESULTS: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a D mean > 40 Gy. Implant loss occurred only in implants with a D mean > 50 Gy. CONCLUSION: An implant-specific D mean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.

KW - dental implants

KW - implant survival

KW - implant-specific dose

KW - Oral cancer

KW - radiotherapy

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U2 - 10.1111/odi.14813

DO - 10.1111/odi.14813

M3 - Article

C2 - 37983849

SN - 1354-523X

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SP - 3866

EP - 3872

JO - Oral diseases

JF - Oral diseases

IS - 6

ER -

Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study

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