Skin and Plasma Autofluorescence During Hemodialysis: A Pilot Study

Reindert Graaff, Stefan Arsov, Bernd Ramsauer, Marten Koetsier, Nils Sundvall, Gerwin E. Engels, Aleksandar Sikole, Lennart Lundberg, Gerhard Rakhorst, Bernd Stegmayr*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    13 Citations (Scopus)

    Abstract

    Skin autofluorescence (AF) is related to the accumulation of advanced glycation end products (AGEs) and is one of the strongest prognostic markers of mortality in hemodialysis (HD) patients. The aim of this pilot study was to investigate whether changes in skin AF appear after a single HD session and if they might be related to changes in plasma AF. Skin and plasma AF were measured before and after HD in 35 patients on maintenance HD therapy (nine women and 26 men, median age 68 years, range 33-83). Median dialysis time was 4h (range 3-5.5). Skin AF was measured noninvasively with an AGE Reader, and plasma AF was measured before and after HD at 460nm after excitation at 370nm. The HD patients had on average a 65% higher skin AF value than age-matched healthy persons (P

    Original languageEnglish
    Pages (from-to)515-518
    Number of pages4
    JournalARTIFICIAL ORGANS
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - Jun-2014

    Keywords

    • Hemodialysis
    • Skin autofluorescence
    • Plasma autofluorescence
    • Advanced glycation end products
    • GLYCATION END-PRODUCTS
    • CHRONIC KIDNEY-DISEASE
    • PREDICTS MORTALITY
    • RISK-FACTORS
    • PROTEIN
    • COMPLICATIONS
    • ACCUMULATION
    • ENDPRODUCTS
    • STRESS
    • MARKER

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