Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is not related to the number of pregnancies

Robert P. Van Waateringe, Laura Truyens, Paul P. Van Den Berg, Helen L. Lutgers, Bruce H. R. Wolffenbuttel*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Abstract

Highlights

Skin autofluorescence (SAF) assesses subcutaneous accumulation of advanced glycation end products and has been shown to predict future cardiovascular disease and diabetes.

A higher number of pregnancies was significantly associated with higher SAF, even after correction for relevant confounders like waist circumference, creatinine clearance, and diabetes status, but not after correction for age.

Women with the highest SAF Z-score had a more unfavorable risk factor profile, with higher body mass index and waist circumference, higher blood pressure, lower high-density lipoprotein cholesterol, and higher triglyceride levels.

Original languageEnglish
Pages (from-to)899-901
Number of pages3
JournalJournal of diabetes
Volume10
Issue number11
DOIs
Publication statusPublished - Nov-2018

Keywords

  • aging
  • diabetes
  • epidemiology
  • pregnancy
  • skin autofluorescence
  • PREECLAMPTIC WOMEN
  • OXIDATIVE STRESS
  • ACCUMULATION
  • ASSOCIATION
  • MARKER

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