Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population

Robert P van Waateringe, Bernardina T Fokkens, Sandra N Slagter, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Andrew D Paterson, Andries J Smit, Helen L Lutgers, Bruce H R Wolffenbuttel

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Abstract

Aims/hypothesisEarlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes. In the present study, we examined whether the measurement of skin autofluorescence can predict 4year risk of incident type 2 diabetes, cardiovascular disease (CVD) and mortality in the general population.MethodsFor this prospective analysis, we included 72,880 participants of the Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007 and 2013, had validated baseline skin autofluorescence values available and were not known to have diabetes or CVD. Individuals were diagnosed with incident type 2 diabetes by self-report or by a fasting blood glucose 7.0mmol/l or HbA(1c) 48mmol/mol (6.5%) at follow-up. Participants were diagnosed as having incident CVD (myocardial infarction, coronary interventions, cerebrovascular accident, transient ischaemic attack, intermittent claudication or vascular surgery) by self-report. Mortality was ascertained using the Municipal Personal Records Database.ResultsAfter a median follow-up of 4years (range 0.5-10years), 1056 participants (1.4%) had developed type 2 diabetes, 1258 individuals (1.7%) were diagnosed with CVD, while 928 (1.3%) had died. Baseline skin autofluorescence was elevated in participants with incident type 2 diabetes and/or CVD and in those who had died (all p

Original languageEnglish
Pages (from-to)269-280
Number of pages12
JournalDiabetologia
Volume62
Issue number2
Early online date21-Nov-2018
DOIs
Publication statusPublished - Feb-2019

Keywords

  • Ageing
  • Cardiovascular
  • Diabetes
  • Mortality
  • Prediction
  • Skin autofluorescence
  • GLYCATION END-PRODUCTS
  • METABOLIC SYNDROME
  • MAILLARD REACTION
  • RISK
  • COMPLICATIONS
  • SCORE
  • GLYCOSYLATION
  • LIFELINES
  • ARTERIAL
  • COLLAGEN

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