Small-animal SPECT and SPECT/CT: application in cardiovascular research

Reza Golestani, Chao Wu, René A Tio, Clark J Zeebregts, Artiom D Petrov, Freek J Beekman, Rudi A J O Dierckx, Hendrikus H Boersma, Riemer H J A Slart

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease.

Original languageEnglish
Pages (from-to)1766-1777
Number of pages12
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number9
DOIs
Publication statusPublished - Aug-2010

Keywords

  • microSPECT
  • microSPECT/CT
  • Cardiovascular imaging
  • ULTRA-HIGH-RESOLUTION
  • IN-VIVO DETECTION
  • COMPUTED TOMOGRAPHY/COMPUTED TOMOGRAPHY
  • ACUTE MYOCARDIAL-INFARCTION
  • PHOTON-EMISSION-TOMOGRAPHY
  • CARDIAC PERFUSION SPECT
  • PINHOLE GATED SPECT
  • HEART-FAILURE
  • MATRIX-METALLOPROTEINASE
  • CELL-DEATH

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