Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness

Hans L. A. Nienhuis; Karina de Leeuw; Johannes Bijzet; Jasper J. van Doormaal; Arie M. van Roon; Andries J. Smit; Reindert Graaff; Cees G. M. Kallenberg; Marc Bijl

doi:10.1186/ar3145

Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness

Hans L. A. Nienhuis^*, Karina de Leeuw, Johannes Bijzet, Jasper J. van Doormaal, Arie M. van Roon, Andries J. Smit, Reindert Graaff, Cees G. M. Kallenberg, Marc Bijl

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

225 Downloads (Pure)

Abstract

Introduction: The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation.

Methods: Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was assessed by pulse-wave analysis using tonometric recordings of the radial artery. IMT of the carotid arteries was measured by ultrasound. AGE accumulation was assessed with an AGE-reader. Endothelial activation markers and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA).

Results: SAE was decreased in SLE (P = 0.01) and further decreased in EH (P <0.01) compared to healthy controls. IMT was increased in EH (P <0.05), but not in SLE. AGE accumulation was increased in SLE (P <0.05) and further increased in EH (P <0.01) compared to healthy controls. Endothelial activation markers and CRP were increased in SLE but not in EH. SAE related to AGE accumulation (r = -0.370, P <0.05), CRP (r = -0.429, P <0.05) and creatinine clearance (r = 0.440, P <0.05), but not to IMT and endothelial activation markers. In multivariate analysis SLE was an independent predictor of SAE.

Conclusions: SAE is decreased in SLE patients without increased IMT, independently of traditional cardiovascular risk factors. Longitudinal studies are needed to investigate whether SAE, endothelial activation and AGE accumulation are early markers for cardiovascular disease in SLE.

Original language	English
Article number	R181
Number of pages	8
Journal	Arthritis Research and Therapy
Volume	12
Issue number	5
DOIs	https://doi.org/10.1186/ar3145
Publication status	Published - 28-Sep-2010

Keywords

C-REACTIVE PROTEIN
ACCELERATED ATHEROSCLEROSIS
RISK-FACTORS
RHEUMATOID-ARTHRITIS
VASCULAR-DISEASE
ENDOTHELIAL DYSFUNCTION
CARDIOVASCULAR-DISEASE
RECEPTOR RAGE
INFLAMMATION
WOMEN

Access to Document

10.1186/ar3145Licence: CC BY

Small artery elasticity is decreasedFinal publisher's version, 273 KBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{fd65bbcc65d948e59a090cbb1409dab3,

title = "Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness",

abstract = "Introduction: The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation.Methods: Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was assessed by pulse-wave analysis using tonometric recordings of the radial artery. IMT of the carotid arteries was measured by ultrasound. AGE accumulation was assessed with an AGE-reader. Endothelial activation markers and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA).Results: SAE was decreased in SLE (P = 0.01) and further decreased in EH (P <0.01) compared to healthy controls. IMT was increased in EH (P <0.05), but not in SLE. AGE accumulation was increased in SLE (P <0.05) and further increased in EH (P <0.01) compared to healthy controls. Endothelial activation markers and CRP were increased in SLE but not in EH. SAE related to AGE accumulation (r = -0.370, P <0.05), CRP (r = -0.429, P <0.05) and creatinine clearance (r = 0.440, P <0.05), but not to IMT and endothelial activation markers. In multivariate analysis SLE was an independent predictor of SAE.Conclusions: SAE is decreased in SLE patients without increased IMT, independently of traditional cardiovascular risk factors. Longitudinal studies are needed to investigate whether SAE, endothelial activation and AGE accumulation are early markers for cardiovascular disease in SLE.",

keywords = "C-REACTIVE PROTEIN, ACCELERATED ATHEROSCLEROSIS, RISK-FACTORS, RHEUMATOID-ARTHRITIS, VASCULAR-DISEASE, ENDOTHELIAL DYSFUNCTION, CARDIOVASCULAR-DISEASE, RECEPTOR RAGE, INFLAMMATION, WOMEN",

author = "Nienhuis, {Hans L. A.} and {de Leeuw}, Karina and Johannes Bijzet and {van Doormaal}, {Jasper J.} and {van Roon}, {Arie M.} and Smit, {Andries J.} and Reindert Graaff and Kallenberg, {Cees G. M.} and Marc Bijl",

year = "2010",

month = sep,

day = "28",

doi = "10.1186/ar3145",

language = "English",

volume = "12",

journal = "Arthritis Research and Therapy",

issn = "1478-6362",

publisher = "BioMed Central Ltd.",

number = "5",

}

TY - JOUR

T1 - Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness

AU - Nienhuis, Hans L. A.

AU - de Leeuw, Karina

AU - Bijzet, Johannes

AU - van Doormaal, Jasper J.

AU - van Roon, Arie M.

AU - Smit, Andries J.

AU - Graaff, Reindert

AU - Kallenberg, Cees G. M.

AU - Bijl, Marc

PY - 2010/9/28

Y1 - 2010/9/28

N2 - Introduction: The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation.Methods: Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was assessed by pulse-wave analysis using tonometric recordings of the radial artery. IMT of the carotid arteries was measured by ultrasound. AGE accumulation was assessed with an AGE-reader. Endothelial activation markers and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA).Results: SAE was decreased in SLE (P = 0.01) and further decreased in EH (P <0.01) compared to healthy controls. IMT was increased in EH (P <0.05), but not in SLE. AGE accumulation was increased in SLE (P <0.05) and further increased in EH (P <0.01) compared to healthy controls. Endothelial activation markers and CRP were increased in SLE but not in EH. SAE related to AGE accumulation (r = -0.370, P <0.05), CRP (r = -0.429, P <0.05) and creatinine clearance (r = 0.440, P <0.05), but not to IMT and endothelial activation markers. In multivariate analysis SLE was an independent predictor of SAE.Conclusions: SAE is decreased in SLE patients without increased IMT, independently of traditional cardiovascular risk factors. Longitudinal studies are needed to investigate whether SAE, endothelial activation and AGE accumulation are early markers for cardiovascular disease in SLE.

AB - Introduction: The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation.Methods: Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was assessed by pulse-wave analysis using tonometric recordings of the radial artery. IMT of the carotid arteries was measured by ultrasound. AGE accumulation was assessed with an AGE-reader. Endothelial activation markers and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA).Results: SAE was decreased in SLE (P = 0.01) and further decreased in EH (P <0.01) compared to healthy controls. IMT was increased in EH (P <0.05), but not in SLE. AGE accumulation was increased in SLE (P <0.05) and further increased in EH (P <0.01) compared to healthy controls. Endothelial activation markers and CRP were increased in SLE but not in EH. SAE related to AGE accumulation (r = -0.370, P <0.05), CRP (r = -0.429, P <0.05) and creatinine clearance (r = 0.440, P <0.05), but not to IMT and endothelial activation markers. In multivariate analysis SLE was an independent predictor of SAE.Conclusions: SAE is decreased in SLE patients without increased IMT, independently of traditional cardiovascular risk factors. Longitudinal studies are needed to investigate whether SAE, endothelial activation and AGE accumulation are early markers for cardiovascular disease in SLE.

KW - C-REACTIVE PROTEIN

KW - ACCELERATED ATHEROSCLEROSIS

KW - RISK-FACTORS

KW - RHEUMATOID-ARTHRITIS

KW - VASCULAR-DISEASE

KW - ENDOTHELIAL DYSFUNCTION

KW - CARDIOVASCULAR-DISEASE

KW - RECEPTOR RAGE

KW - INFLAMMATION

KW - WOMEN

U2 - 10.1186/ar3145

DO - 10.1186/ar3145

M3 - Article

C2 - 20920173

VL - 12

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

SN - 1478-6362

IS - 5

M1 - R181

ER -