Abstract
The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems. Into the cell: The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of cystic fibrosis, and in treating cancer by perturbing chemical gradients within cells, is currently an area of intense interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.
| Original language | English |
|---|---|
| Pages (from-to) | 1374-1382 |
| Number of pages | 9 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 28-Jan-2013 |
| Externally published | Yes |
Keywords
- anions
- hydrogen bonding
- ion transport
- membranes
- supramolecular chemistry