SNARE derived peptide mimic inducing membrane fusion

K. Meyerberg; A.S. Lygina; Geert van den Bogaart; Reinhard Jahn; U. Diederichsen

doi:10.1039/c1cc12879e

SNARE derived peptide mimic inducing membrane fusion

K. Meyerberg, A.S. Lygina, Geert van den Bogaart, Reinhard Jahn, U. Diederichsen

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

Abstract

SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

Original language	English
Pages (from-to)	9405-9407
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	33
DOIs	https://doi.org/10.1039/c1cc12879e
Publication status	Published - Jul-2011
Externally published	Yes

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@article{33b975dd980a476596701c01d6eb3404,

title = "SNARE derived peptide mimic inducing membrane fusion",

abstract = "SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.",

author = "K. Meyerberg and A.S. Lygina and {van den Bogaart}, Geert and Reinhard Jahn and U. Diederichsen",

year = "2011",

month = jul,

doi = "10.1039/c1cc12879e",

language = "English",

volume = "47",

pages = "9405--9407",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

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T1 - SNARE derived peptide mimic inducing membrane fusion

AU - Meyerberg, K.

AU - Lygina, A.S.

AU - van den Bogaart, Geert

AU - Jahn, Reinhard

AU - Diederichsen, U.

PY - 2011/7

Y1 - 2011/7

N2 - SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

AB - SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

U2 - 10.1039/c1cc12879e

DO - 10.1039/c1cc12879e

M3 - Article

SN - 1359-7345

VL - 47

SP - 9405

EP - 9407

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

SNARE derived peptide mimic inducing membrane fusion

Abstract

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