SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales

Anu Realo; Peter J. van der Most; Juri Allik; Tonu Esko; Bertus F. Jeronimus; Liisi Koots-Ausmees; Rene Mottus; Felix C. Tropf; Harold Snieder; Johan Ormel

doi:10.1111/jopy.12297

SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales

Anu Realo^*, Peter J. van der Most, Juri Allik, Tonu Esko, Bertus F. Jeronimus, Liisi Koots-Ausmees, Rene Mottus, Felix C. Tropf, Harold Snieder, Johan Ormel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).

Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self-and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.

Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self-and informant-reported Neuroticism domain scores was 15.2% (p=.070, SE=.11) and 6.2% (p=.293, SE=.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self-than for informant reports, and (b) for sum than for residual scores.

Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.

Original language	English
Pages (from-to)	906-919
Number of pages	14
Journal	Journal of Personality
Volume	85
Issue number	6
Early online date	13-Feb-2017
DOIs	https://doi.org/10.1111/jopy.12297
Publication status	Published - Dec-2017

Keywords

Neuroticism
GREML-GCTA
SNP-based heritability
self-versus informant reports
sum versus residual scores
GENOME-WIDE ASSOCIATION
MAJOR DEPRESSIVE DISORDER
CROSS-CULTURAL TWIN
NEO-PI-R
MISSING HERITABILITY
GENETIC-VARIATION
HUMAN PERSONALITY
ENVIRONMENTAL-INFLUENCES
PSYCHOBIOLOGICAL MODEL
POLYMORPHISM 5-HTTLPR

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Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, H. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006
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@article{0f607d43eb8a40c9928183ad390809be,

title = "SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales",

abstract = "Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self-and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self-and informant-reported Neuroticism domain scores was 15.2% (p=.070, SE=.11) and 6.2% (p=.293, SE=.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self-than for informant reports, and (b) for sum than for residual scores.Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.",

keywords = "Neuroticism, GREML-GCTA, SNP-based heritability, self-versus informant reports, sum versus residual scores, GENOME-WIDE ASSOCIATION, MAJOR DEPRESSIVE DISORDER, CROSS-CULTURAL TWIN, NEO-PI-R, MISSING HERITABILITY, GENETIC-VARIATION, HUMAN PERSONALITY, ENVIRONMENTAL-INFLUENCES, PSYCHOBIOLOGICAL MODEL, POLYMORPHISM 5-HTTLPR",

author = "Anu Realo and {van der Most}, {Peter J.} and Juri Allik and Tonu Esko and Jeronimus, {Bertus F.} and Liisi Koots-Ausmees and Rene Mottus and Tropf, {Felix C.} and Harold Snieder and Johan Ormel",

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year = "2017",

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doi = "10.1111/jopy.12297",

language = "English",

volume = "85",

pages = "906--919",

journal = "Journal of Personality",

issn = "0022-3506",

publisher = "Wiley",

number = "6",

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SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales. / Realo, Anu; van der Most, Peter J.; Allik, Juri; Esko, Tonu; Jeronimus, Bertus F.; Koots-Ausmees, Liisi; Mottus, Rene; Tropf, Felix C.; Snieder, Harold ; Ormel, Johan.

In: Journal of Personality, Vol. 85, No. 6, 12.2017, p. 906-919.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales

AU - Realo, Anu

AU - van der Most, Peter J.

AU - Allik, Juri

AU - Esko, Tonu

AU - Jeronimus, Bertus F.

AU - Koots-Ausmees, Liisi

AU - Mottus, Rene

AU - Tropf, Felix C.

AU - Snieder, Harold

AU - Ormel, Johan

PY - 2017/12

Y1 - 2017/12

N2 - Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self-and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self-and informant-reported Neuroticism domain scores was 15.2% (p=.070, SE=.11) and 6.2% (p=.293, SE=.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self-than for informant reports, and (b) for sum than for residual scores.Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.

AB - Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self-and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self-and informant-reported Neuroticism domain scores was 15.2% (p=.070, SE=.11) and 6.2% (p=.293, SE=.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self-than for informant reports, and (b) for sum than for residual scores.Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.

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KW - SNP-based heritability

KW - self-versus informant reports

KW - sum versus residual scores

KW - GENOME-WIDE ASSOCIATION

KW - MAJOR DEPRESSIVE DISORDER

KW - CROSS-CULTURAL TWIN

KW - NEO-PI-R

KW - MISSING HERITABILITY

KW - GENETIC-VARIATION

KW - HUMAN PERSONALITY

KW - ENVIRONMENTAL-INFLUENCES

KW - PSYCHOBIOLOGICAL MODEL

KW - POLYMORPHISM 5-HTTLPR

U2 - 10.1111/jopy.12297

DO - 10.1111/jopy.12297

M3 - Article

C2 - 27977872

VL - 85

SP - 906

EP - 919

JO - Journal of Personality

JF - Journal of Personality

SN - 0022-3506

IS - 6

ER -

SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales

Abstract

Keywords

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Lifelines Biobank

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