Sodium intake affects urinary albumin excretion especially in overweight subjects

J C Verhave, H L Hillege, J G M Burgerhof, W M T Janssen, R T Gansevoort, G J Navis, D de Zeeuw, P E de Jong, PREVEND Study Group, Maarten Postma

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154 Citations (Scopus)

Abstract

Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality.

Design. Cross-sectional cohort study using linear regression analysis.

Setting: University hospital outpatient clinic.

Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration.

Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI.

Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.

Original languageEnglish
Pages (from-to)324-330
Number of pages7
JournalJournal of Internal Medicine
Volume256
Issue number4
DOIs
Publication statusPublished - Oct-2004

Keywords

  • cardiovascular risk factor
  • microalbuminuria
  • obesity
  • urinary sodium excretion
  • BODY-MASS INDEX
  • BLOOD-PRESSURE
  • DIETARY-SODIUM
  • HEALTHY-SUBJECTS
  • ACE-INHIBITION
  • OBESE-PATIENTS
  • MICROALBUMINURIA
  • HYPERTENSION
  • POPULATION
  • DISEASE

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