Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study.

R Renken; L Muresan; H Duifhuis; JBTM Roerdink

Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study.

R Renken^*, L Muresan, H Duifhuis, JBTM Roerdink

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

In fMRI, any fluctuation of signal intensity, not recognized as a result of a specific task, is treated as noise. One source for "noise" is subject motion. Normally, motion effects are reduced by applying realignment. We investigate how apt a realignment procedure is in removing motion-related effects by comparing the distribution of the normnalized standard deviation of each voxel, NSD (=standard deviation/mean), before and after realignment.

We use data acquired from a simulation program developed previously. This program covers the effects of spin history, slice profiles, and motion in (f)MRI. We simulated inter-volume motion perpendicular to the slices of a digital, artificial head phantom, with and without spin history. In all cases, fluctuations in signal intensity were reduced after standard realignment. This effect was. strongest when no spin history was present. Hence, spin history has a marked effect on the "noise".

The spatial distribution of NSD showed similarities to the structures of the. brain. This indicates that (residual) motion effects were largest at the transitions between tissues. Possibly, the spatial distribution of NSD can provide a (independent) tool to investigate brain structure. Furthermore, the method presented can be used to qualitatively compare different "noise" reduction steps in fMRI data analysis.

Original language	English
Title of host publication	MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2
Editors	MK Yaffe, LE Antonuk
Place of Publication	BELLINGHAM
Publisher	SPIE - INT SOC OPTICAL ENGINEERING
Pages	603-610
Number of pages	8
ISBN (Print)	0-8194-4831-1
Publication status	Published - 2003
Event	Medical Imaging 2003 Conference - , Canada Duration: 17-Feb-2003 → 20-Feb-2003

Publication series

Name	PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)
Publisher	SPIE-INT SOC OPTICAL ENGINEERING
Volume	5030
ISSN (Print)	0277-786X

Other

Other	Medical Imaging 2003 Conference
Country/Territory	Canada
Period	17/02/2003 → 20/02/2003

Keywords

fMRI
motion
artifacts
spin history
simulation
TIME-SERIES

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Renken, R., Muresan, L., Duifhuis, H., & Roerdink, JBTM. (2003). Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study. In MK. Yaffe, & LE. Antonuk (Eds.), MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2 (pp. 603-610). (PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE); Vol. 5030). SPIE - INT SOC OPTICAL ENGINEERING.

Renken, R ; Muresan, L ; Duifhuis, H et al. / Space-dependent effects of motion on the standard deviation of fMRI signals : a simulation study. MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2. editor / MK Yaffe ; LE Antonuk. BELLINGHAM : SPIE - INT SOC OPTICAL ENGINEERING, 2003. pp. 603-610 (PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)).

@inproceedings{58f09449e3834a4f9f2b47506bb814d7,

title = "Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study.",

abstract = "In fMRI, any fluctuation of signal intensity, not recognized as a result of a specific task, is treated as noise. One source for {"}noise{"} is subject motion. Normally, motion effects are reduced by applying realignment. We investigate how apt a realignment procedure is in removing motion-related effects by comparing the distribution of the normnalized standard deviation of each voxel, NSD (=standard deviation/mean), before and after realignment.We use data acquired from a simulation program developed previously. This program covers the effects of spin history, slice profiles, and motion in (f)MRI. We simulated inter-volume motion perpendicular to the slices of a digital, artificial head phantom, with and without spin history. In all cases, fluctuations in signal intensity were reduced after standard realignment. This effect was. strongest when no spin history was present. Hence, spin history has a marked effect on the {"}noise{"}.The spatial distribution of NSD showed similarities to the structures of the. brain. This indicates that (residual) motion effects were largest at the transitions between tissues. Possibly, the spatial distribution of NSD can provide a (independent) tool to investigate brain structure. Furthermore, the method presented can be used to qualitatively compare different {"}noise{"} reduction steps in fMRI data analysis.",

keywords = "fMRI, motion, artifacts, spin history, simulation, TIME-SERIES",

author = "R Renken and L Muresan and H Duifhuis and JBTM Roerdink",

year = "2003",

language = "English",

isbn = "0-8194-4831-1",

series = "PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)",

publisher = "SPIE - INT SOC OPTICAL ENGINEERING",

pages = "603--610",

editor = "MK Yaffe and LE Antonuk",

booktitle = "MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2",

note = "Medical Imaging 2003 Conference ; Conference date: 17-02-2003 Through 20-02-2003",

}

Renken, R, Muresan, L, Duifhuis, H & Roerdink, JBTM 2003, Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study. in MK Yaffe & LE Antonuk (eds), MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2. PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE), vol. 5030, SPIE - INT SOC OPTICAL ENGINEERING, BELLINGHAM, pp. 603-610, Medical Imaging 2003 Conference, Canada, 17/02/2003.

Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study. / Renken, R; Muresan, L; Duifhuis, H et al.
MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2. ed. / MK Yaffe; LE Antonuk. BELLINGHAM: SPIE - INT SOC OPTICAL ENGINEERING, 2003. p. 603-610 (PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE); Vol. 5030).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Space-dependent effects of motion on the standard deviation of fMRI signals

T2 - Medical Imaging 2003 Conference

AU - Renken, R

AU - Muresan, L

AU - Duifhuis, H

AU - Roerdink, JBTM

PY - 2003

Y1 - 2003

N2 - In fMRI, any fluctuation of signal intensity, not recognized as a result of a specific task, is treated as noise. One source for "noise" is subject motion. Normally, motion effects are reduced by applying realignment. We investigate how apt a realignment procedure is in removing motion-related effects by comparing the distribution of the normnalized standard deviation of each voxel, NSD (=standard deviation/mean), before and after realignment.We use data acquired from a simulation program developed previously. This program covers the effects of spin history, slice profiles, and motion in (f)MRI. We simulated inter-volume motion perpendicular to the slices of a digital, artificial head phantom, with and without spin history. In all cases, fluctuations in signal intensity were reduced after standard realignment. This effect was. strongest when no spin history was present. Hence, spin history has a marked effect on the "noise".The spatial distribution of NSD showed similarities to the structures of the. brain. This indicates that (residual) motion effects were largest at the transitions between tissues. Possibly, the spatial distribution of NSD can provide a (independent) tool to investigate brain structure. Furthermore, the method presented can be used to qualitatively compare different "noise" reduction steps in fMRI data analysis.

AB - In fMRI, any fluctuation of signal intensity, not recognized as a result of a specific task, is treated as noise. One source for "noise" is subject motion. Normally, motion effects are reduced by applying realignment. We investigate how apt a realignment procedure is in removing motion-related effects by comparing the distribution of the normnalized standard deviation of each voxel, NSD (=standard deviation/mean), before and after realignment.We use data acquired from a simulation program developed previously. This program covers the effects of spin history, slice profiles, and motion in (f)MRI. We simulated inter-volume motion perpendicular to the slices of a digital, artificial head phantom, with and without spin history. In all cases, fluctuations in signal intensity were reduced after standard realignment. This effect was. strongest when no spin history was present. Hence, spin history has a marked effect on the "noise".The spatial distribution of NSD showed similarities to the structures of the. brain. This indicates that (residual) motion effects were largest at the transitions between tissues. Possibly, the spatial distribution of NSD can provide a (independent) tool to investigate brain structure. Furthermore, the method presented can be used to qualitatively compare different "noise" reduction steps in fMRI data analysis.

KW - fMRI

KW - motion

KW - artifacts

KW - spin history

KW - simulation

KW - TIME-SERIES

M3 - Conference contribution

SN - 0-8194-4831-1

T3 - PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)

SP - 603

EP - 610

BT - MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2

A2 - Yaffe, MK

A2 - Antonuk, LE

PB - SPIE - INT SOC OPTICAL ENGINEERING

CY - BELLINGHAM

Y2 - 17 February 2003 through 20 February 2003

ER -

Renken R, Muresan L, Duifhuis H, Roerdink JBTM. Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study. In Yaffe MK, Antonuk LE, editors, MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2. BELLINGHAM: SPIE - INT SOC OPTICAL ENGINEERING. 2003. p. 603-610. (PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)).

Space-dependent effects of motion on the standard deviation of fMRI signals: a simulation study.

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