Specific electrochemical cleavage of peptides with on-line mass spectrometric detection

H. P. Permentier; J. U. Jurva; M. B. Barroso; R. Bischoff; A. P. Bruins

Specific electrochemical cleavage of peptides with on-line mass spectrometric detection

H. P. Permentier^*
, J. U. Jurva
, M. B. Barroso
, R. Bischoff
, A. P. Bruins

^*Corresponding author for this work

Research output: Contribution to conference › Paper › Academic

Abstract

The feasibility of subjecting peptides to electrochemical reactions was investigated. On-line mass spectrometry was used for the analysis. The on-line combination of an electrochemical flow cell with electrospray mass spectrometry offers quick insight into the scope and limitations of electrochemical reactions of organic molecules. It was shown that specific cleavage at tyrosine occurs and that phosphorylation of tyrosine prevents the cleavage.

Original language	English
Pages	133-134
Number of pages	2
Publication status	Published - 2002
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2-Jun-2002 → 6-Jun-2002

Conference

Conference	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	02/06/2002 → 06/06/2002

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Permentier, H. P., Jurva, J. U., Barroso, M. B., Bischoff, R., & Bruins, A. P. (2002). Specific electrochemical cleavage of peptides with on-line mass spectrometric detection. 133-134. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States. https://www.scopus.com/record/display.uri?eid=2-s2.0-2442690478&origin=inward&txGid=81563cef256622de0b8bdf4888268470

@conference{c8e6da90cee24ccdb73d94d311a4b886,

title = "Specific electrochemical cleavage of peptides with on-line mass spectrometric detection",

abstract = "The feasibility of subjecting peptides to electrochemical reactions was investigated. On-line mass spectrometry was used for the analysis. The on-line combination of an electrochemical flow cell with electrospray mass spectrometry offers quick insight into the scope and limitations of electrochemical reactions of organic molecules. It was shown that specific cleavage at tyrosine occurs and that phosphorylation of tyrosine prevents the cleavage.",

author = "Permentier, \{H. P.\} and Jurva, \{J. U.\} and Barroso, \{M. B.\} and R. Bischoff and Bruins, \{A. P.\}",

year = "2002",

language = "English",

pages = "133--134",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

}

Permentier, HP, Jurva, JU, Barroso, MB, Bischoff, R & Bruins, AP 2002, 'Specific electrochemical cleavage of peptides with on-line mass spectrometric detection', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 02/06/2002 - 06/06/2002 pp. 133-134. <https://www.scopus.com/record/display.uri?eid=2-s2.0-2442690478&origin=inward&txGid=81563cef256622de0b8bdf4888268470>

TY - CONF

T1 - Specific electrochemical cleavage of peptides with on-line mass spectrometric detection

AU - Permentier, H. P.

AU - Jurva, J. U.

AU - Barroso, M. B.

AU - Bischoff, R.

AU - Bruins, A. P.

PY - 2002

Y1 - 2002

N2 - The feasibility of subjecting peptides to electrochemical reactions was investigated. On-line mass spectrometry was used for the analysis. The on-line combination of an electrochemical flow cell with electrospray mass spectrometry offers quick insight into the scope and limitations of electrochemical reactions of organic molecules. It was shown that specific cleavage at tyrosine occurs and that phosphorylation of tyrosine prevents the cleavage.

AB - The feasibility of subjecting peptides to electrochemical reactions was investigated. On-line mass spectrometry was used for the analysis. The on-line combination of an electrochemical flow cell with electrospray mass spectrometry offers quick insight into the scope and limitations of electrochemical reactions of organic molecules. It was shown that specific cleavage at tyrosine occurs and that phosphorylation of tyrosine prevents the cleavage.

M3 - Paper

AN - SCOPUS:2442690478

SP - 133

EP - 134

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Specific electrochemical cleavage of peptides with on-line mass spectrometric detection

Abstract

Conference

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