Sphingolipid trafficking and protein sorting in epithelial cells

TA Slimane, D Hoekstra*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Citations (Scopus)

Abstract

Sphingolipids represent a minor, but highly dynamic subclass of lipids in all eukaryotic cells. They are involved in functions that range from structural protection to signal transduction and protein sorting, and participate in lipid raft assembly. In polarized epithelial cells, which display an asymmetric apical and basolateral membrane surface, rafts have been proposed as a sorting principle for apical resident proteins, following their biosynthesis. However, raft-mediated trafficking is ubiquitous in cells. Also, sphingolipids per se, which are strongly enriched in the apical domain, are subject to sorting in polarity development. Next to the trans Golgi network, a subapical compartment called SAC or common endosome appears instrumental in regulating these sorting events. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

Original languageEnglish
Article numberPII S0014-5793(02)03183-6
Pages (from-to)54-59
Number of pages6
JournalFEBS Letters
Volume529
Issue number1
Publication statusPublished - 2-Oct-2002

Keywords

  • sphingolipid
  • subapical compartment
  • cell polarity
  • sorting
  • trafficking
  • DARBY CANINE KIDNEY
  • APICAL PLASMA-MEMBRANE
  • TRANS-GOLGI NETWORK
  • INFLUENZA-VIRUS HEMAGGLUTININ
  • POLARIZED MDCK CELLS
  • SUBAPICAL COMPARTMENT
  • HEPG2 CELLS
  • SPHINGOMYELIN SYNTHESIS
  • NONVESICULAR TRANSPORT
  • LIPID MICRODOMAINS

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