sphingosine-1-phosphate transport and its role in immunology

V. Reitsema, Hjalmar Bouma, Jan Kok

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Abstract

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite with many important functions in cellular and systemic physiology, including the immune system. As it cannot traverse the membrane, it is exported from cells by transporters. Several members of the ATP-binding cassette (ABC) transporter family, ABCA1, ABCC1, ABCG2 and potentially ABCA7 have been identified as S1P transporters. In addition spinster 2 (SPNS2), a protein from the major facilitator superfamily (MFS), was identified as a S1P transporter. Here we review the current knowledge on S1P transport and discuss how this process creates S1P gradients in the body that are important in various functions of the immune system. - See more at: http://www.aimspress.com/aimsmoles/ch/reader/view_abstract.aspx?file_no=MolSci2014013&flag=1#sthash.dn7zCE1L.dpuf
Original languageEnglish
Pages (from-to)183-201
Number of pages18
JournalAIMS Molecular Science
Volume1
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • ABC transporter
  • SPNS2

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