Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds

Branko Jenko; Gregor Kosec; Hrvoje Petkovic; Ajda  Podgorsek Berke; Jerca Pahor; Alen Čusak; Oda Sibon; Balaji Srinivasan

Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds

Branko Jenko (Inventor), Gregor Kosec (Inventor), Hrvoje Petkovic (Inventor), Ajda Podgorsek Berke (Inventor), Jerca Pahor (Inventor), Alen Čusak (Inventor), Oda Sibon (Inventor), Balaji Srinivasan (Inventor)

Movement Disorder (MD)

Research output: Patent

Abstract

The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

Original language	English
Patent number	WO2015063177
Priority date	04/11/2013
Publication status	Published - 7-May-2015

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Jenko, B., Kosec, G., Petkovic, H., Podgorsek Berke, A., Pahor, J., Čusak, A., Sibon, O., & Srinivasan, B. (2015). Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds. (Patent No. WO2015063177). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2015063177A1&KC=A1&FT=D&ND=3&date=20150507&DB=&locale=en_EP

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abstract = "The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.",

author = "Branko Jenko and Gregor Kosec and Hrvoje Petkovic and {Podgorsek Berke}, Ajda and Jerca Pahor and Alen {\v C}usak and Oda Sibon and Balaji Srinivasan",

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Jenko, B, Kosec, G, Petkovic, H, Podgorsek Berke, A, Pahor, J, Čusak, A, Sibon, O & Srinivasan, B May. 07 2015, Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds, Patent No. WO2015063177. <https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2015063177A1&KC=A1&FT=D&ND=3&date=20150507&DB=&locale=en_EP>

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T1 - Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds

AU - Jenko, Branko

AU - Kosec, Gregor

AU - Petkovic, Hrvoje

AU - Podgorsek Berke, Ajda

AU - Pahor, Jerca

AU - Čusak, Alen

AU - Sibon, Oda

AU - Srinivasan, Balaji

PY - 2015/5/7

Y1 - 2015/5/7

N2 - The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

AB - The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

M3 - Patent

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